Research Scientist - Contractor

About the role

Prelude Therapeutics is an early-stage biotechnology company founded by proven scientists in cancer drug development. The Research Scientist will play a key role in designing and developing a pipeline of novel therapies for cancer patients, with a focus on small molecule drugs, targeted protein degraders, and conjugates including Degrader-Antibody Conjugates (DACs) and Antibody-Drug Conjugates (ADCs). We offer a vibrant, collegial work environment and excellent career growth opportunities at our Wilmington, DE location, ideally situated within 25 minutes of Philadelphia International Airport.

Responsibilities

• Evaluate the potency and selectivity of new molecules in various functional and phenotypic cell-based assays.
• Characterize new molecules through mechanism of action studies.
• Develop, validate, and optimize assay systems to support the detection of cellular and tissue pharmacodynamic markers.
• Conduct specific assays related to degraders, DACs, and ADCs, such as antibody internalization, target degradation, and payload release assays.
• Maintain accurate records of experiments, analyze and interpret results, present summaries, and generate reports of the studies.
• Contribute to project planning and strategy, ensuring timely progress and troubleshooting of experimental challenges.

Qualifications

Education: PhD with 0-3 years of relevant post-doctoral or industry research experience, or MS with 3-6 years of relevant research experience.

Skills

• Hands-on experience with cell/tissue culture, cell viability assays, immunoblotting, quantitative RT-PCR, and flow cytometry.
• Experience with the Incucyte platform for live-cell imaging and analysis.
• Hands-on experience working with therapeutic antibodies is preferred, particularly in the context of targeted protein degraders, Degrader-Antibody Conjugates (DACs), and/or Antibody-Drug Conjugates (ADCs).
• Proficiency in data analysis and presentation software.

Personal Characteristics

• Highly self-motivated, with excellent verbal and written communication skills.
• Ability to work efficiently both independently and in a team/matrix environment.
• Organized and detail-oriented, with strong problem-solving skills.

Additional Information

This is an on-site, contract position (1 year) at our Wilmington, DE site, requiring 90% wet lab work and hands-on experimental tasks. Personal transportation is necessary to access the site.