Jobs · OTHR · North Carolina

Research Scientist

BioSpace · Durham, NC · 3 wk ago
On-siteOTHR$124k–$186k/yrFull-time

About the role

Responsible for designing and executing experiments relating to the efficacy and mechanism of action of anticancer compounds with little supervision, with a specific focus on neuro-oncology. Responsible for documenting and archiving experimental protocols, data, analyses, and conclusions according to established laboratory procedures. Expected to participate in communication of research into publications, conference presentations, abstracts, and patent applications. Self-motivated and works under general supervision on multiple projects. This position is a full time laboratory-based position.

Essential Functions/Responsibilities

  • Manage cell culture of cancers, including neurospheres
  • Perform in vitro efficacy, mechanism of action, target validation, and biomarker studies with cancer therapeutics, with an emphasis on CNS tumor models.
  • Create stable cell lines with CRISPR and inducible expression of relevant biomarkers.
  • Create or adapt reporter systems for relevant molecular targets.
  • Present summary results for internal communications and external presentations.
  • Support preparation of conference abstracts and manuscripts for publication as needed.
  • Develop proper operational, data documentation, and troubleshooting procedures.

Required Knowledge, Skills, and Abilities

  • Five or more years of industry or post-doctoral experience on the bench dedicated to neuro-oncology.
  • Demonstrated expertise in neuro-oncology biology, as well as therapeutics.
  • Experience in oncology and pharmacology assays and techniques.
  • Exceptional written and verbal communication including publications and conference presentations.
  • Team player who is highly organized and able to manage multiple concurrent projects with minimal oversight.
  • Forward-thinking with the ability to anticipate challenges and proactively implement solutions.
  • Computer proficient.
  • Experience driving advancement of numerous projects simultaneously.
  • Able to identify and initiate tasks, set goals for completion, create timelines, and monitor progress to ensure completion.
  • Strong sense of urgency to meet business needs.
  • A positive, "hands-on" approach to the position.
  • Demonstrated ability to react and respond professionally to changing priorities and timelines.
  • Demonstrated success in working in a matrix, cross-functional environment.
  • Demonstrated ability to communicate clearly both written and oral and work independently with a high level of attention to detail.

Required/Preferred Education and Licenses

  • Ph.D. in cancer biology, molecular/cell biology, biochemistry, pharmacology, or related fields, or master’s degree with relevant experience.

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