Research Fellow - Neurology

Role Overview The postdoctoral fellow will contribute to a rare disease therapeutics program focused on POLR2A-related disorders, with broader work on genetic forms of ALS and monogenic neurological conditions. Key Responsibilities Develop and characterize patient-derived and engineered disease models, including iPSC-derived neural cells and organoids.Perform molecular, cellular, imaging, electrophysiologic, and genomics assays to investigate variant effects, disease mechanisms, and therapeutic responses.Design and evaluate RNA-targeted therapies and gene-editing strategies, such as ASOs, siRNA, CRISPR, and delivery systems.Integrate genomic data with functional readouts to prioritize treatment approaches and elucidate disease mechanisms.Collaborate with clinical teams, core facilities, and external partners to align research efforts and translate findings.Prepare scientific reports, manuscripts, presentations, and grant applications; mentor junior team members. Qualifications & Skills Ph.D., M.D./Ph.D., or equivalent in neuroscience, genetics, molecular/cell biology, or related fields.Experience in cell-based disease modeling, functional genomics, therapeutic development, or neurogenetics.Strong wet-lab skills in cell culture, molecular techniques, sequencing, and imaging.Ability to analyze complex data using tools like R, Python, or Prism.Excellent organization, independence, communication, and collaboration skills.Preferred experience with iPSC neural models, RNA therapeutics, genome editing, rare disease research, or biomarker discovery.