Research Associate, Translational Biology (CONTRACT)

About the Role

This is a contracted position requiring 20-30 hours per week for a 6-month term. The Veterinary Technician / Research Associate will initially be responsible for conducting in vivo rodent studies, with the potential to engage in additional ex vivo or in vitro studies in the Translational Sciences Department to support the advancement of Septerna's small molecule drug discovery pipeline. The candidate will work independently and collaboratively in an inter-disciplinary setting to execute experiments in preclinical models to understand in vivo pharmacology, establish PK/PD relationships, and inform the efficacy of Septerna's therapeutic candidates. They will help generate in vivo and/or ex vivo data to determine therapeutic mechanisms of action, in vivo efficacy, and rank candidates for preclinical development. This role is expected to be primarily in the lab with some desk work. Regular weekend working hours will be required. The position is based in South San Francisco, CA.

Responsibilities

• Execute in vivo pharmacology studies to understand therapeutic mechanisms in relevant disease models
• Work collaboratively to determine the mechanism of action of drug candidates, primarily with in vivo models
• Be a member of multiple project teams
• Dose large volumes of animals (approx. 50-80 rats per day)
• Maintain and organize lab spaces
• Follow all company policies/practices, and maintain accurate records and notebooks
• Perform routine weekend study activities

Required Experience & Skills

• At least 2 years direct full-time experience with in vivo studies in academia or the biotechnology and pharmaceutical industries
• Experience working in vivarium laboratory settings with rats
• Demonstrated ability to be hands on and work directly with rodent models, including multiple routes of administration (e.g. oral, subcutaneous, intraperitoneal, intravenous, intramuscular) and sample collection (e.g. tail vein bleeds, jugular bleeds, cardiac puncture, necropsies, etc.)
• Experience working with other scientists to collect and record study data consistently and accurately
• Ability to collaborate and trouble-shoot biological experiments
• Detail-oriented and organized, with strong interpersonal skills for clear and effective communication - ability to proactively engage and collaboration with colleagues

Preferred Qualifications

• BSc in Pharmacology, Toxicology, Animal Science, or related biological science
• Experience working with in vitro/ex vivo protein and RNA/DNA assays (e.g. ELISA, qPCR)
• Experience with subcutaneous injections and oral gavage routes of administration
• Experience collecting and processing blood samples, especially timed blood collections
• Experience with cell culture
• Experience with data analysis using Excel and/or Prism
• Experience working with rodent surgical models
• Previous work on therapeutic discovery and development programs in the field of endocrine, inflammatory, neuroscience, or metabolic diseases

Pay

The anticipated salary range for candidates who will work in South San Francisco, CA is $30.00/hr - $40.00/hr. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training.