Research Associate II – Molecular Assay Development
About the Company
Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights. We are a highly collaborative, R&D-driven team operating in a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications. At Sarmal, we value scientific rigor, curiosity, and a builder mindset.
About the Role
The Research Associate II will support the development and optimization of molecular diagnostic assays for Sarmal's pathogen detection platform. This individual will execute surface-based nucleic acid detection assays, prepare reagents and master mixes, perform fluorescence- and CE-based experiments, analyze experimental data, troubleshoot assay performance, and document results. The ideal candidate is highly organized, detail-oriented, and enjoys hands-on laboratory work in a collaborative, fast-paced startup environment with evolving priorities.
Responsibilities
- Execute surface-based nucleic acid detection assays using 96- and 384-well plate formats following established protocols.
- Prepare master mixes, serial dilutions, oligonucleotides, enzyme reagents, and working stocks with high accuracy and reproducibility.
- Perform fluorescence plate-based assays, capillary electrophoresis sample preparation, and routine instrument operation.
- Analyze experimental data, summarize results, and present findings to the Assay Development team.
- Assist in optimizing assay performance through systematic troubleshooting and experimental evaluation.
- Maintain accurate laboratory notebooks, experimental records, and SOP documentation.
- Support reagent inventory, laboratory organization, and routine laboratory operations.
- Contribute to assay verification, reproducibility studies, and technology transfer activities as needed.
Qualifications
- Hands-on laboratory experience with molecular biology or biochemical assays, including 96- or 384-well plate-based workflows.
- Experience with nucleic acid hybridization assays, fluorescence-based detection methods, enzymatic reactions, or surface-based capture assays.
- Experience preparing master mixes, serial dilutions, reagent stocks, and low-volume liquid handling.
- Familiarity with fluorescence plate readers, capillary electrophoresis, or similar analytical instrumentation.
- Ability to analyze experimental data using Excel; experience with JMP or similar software is a plus.
- Strong troubleshooting skills, attention to detail, and ability to maintain high-quality experimental documentation.
- Ability to independently execute experiments while effectively collaborating within a multidisciplinary team.
- Experience with automated liquid handling systems (Hamilton, Tecan, Beckman, Opentrons, or similar) is a plus.
- Experience working in a regulated diagnostics, biotechnology, or medical device environment is desirable.
Education
- B.S. or M.S. in Molecular Biology, Biochemistry, Biotechnology, or a related field.
- B.S. with 2-4 years or M.S. with 1–2 years of relevant industry experience.
- Demonstrated hands-on experience performing molecular biology or assay development experiments in an industrial or translational research environment.
- Experience with nucleic acid hybridization, fluorescence-based assays, surface-based assay formats, or molecular diagnostics is strongly preferred.
- Experience supporting assay optimization, troubleshooting, or analytical method development is highly desirable.
Benefits
- Medical, dental, and vision coverage
- Company-paid life insurance
- 401(k) retirement plan
- Generous paid time off
- Access to additional voluntary benefits, employee perks, and discount programs
Pay
$72,000 - $85,000 a year. The anticipated salary range for this position is $72,000 – $85,000, depending on experience and qualifications. Final compensation will be determined based on a variety of factors including, but not limited to, location, relevant experience, skill set, and internal equity considerations.
Why Join Sarmal
- Work on cutting-edge genomics and molecular detection technologies
- Collaborate with a deeply technical, cross-functional team
- Contribute to foundational platform development at an early stage
- Have visibility into and impact on core technical and strategic decisions
- Help shape the infrastructure, culture, and future direction of the company