Research Associate II/III– Bioanalytical/In Vitro ADME/DMPK

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines. We aim to improve treatment options for patients with cancer and inflammatory diseases through a fully AI-integrated discovery engine and unparalleled ligase expertise.

About the role

The successful candidate will contribute to bioanalytical efforts supporting Nurix drug discovery programs, including in vivo and in vitro studies. This role involves characterizing the in vitro and in vivo ADME properties of drug candidates, developing bioanalytical methods, quantitating drug candidates and metabolites, and managing outsourced projects to support all studies.

Responsibilities

• Provide bioanalytical support for in-house PK and non-GLP safety TK studies.
• Develop and qualify bioanalytical methods to support drug, metabolite, and biomarker analysis.
• Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples.
• Conduct in-vitro stability assays to understand drug metabolism.
• Perform metabolic identification (MetID) using LC-QTOF MS/MS, including accurate mass analysis, fragment interpretation, and biotransformation pathway assignment.
• Independently operate, troubleshoot, and maintain LC-MS/MS systems.
• Participate in multidisciplinary project teams and collaborate with other departments to address bioanalytical needs for PK and PD support.
• Manage projects conducted at CROs to ensure high-quality bioanalytical data is delivered on time.
• Maintain accurate and detailed scientific electronic laboratory notebooks.
• Perform sample analysis to support PK, PK/PD, PK/efficacy, distribution, metabolism, and non-GLP toxicology studies.
• Identify issues and troubleshoot scientific equipment, including LC-MS/MS, select and develop methods, analyze data, and prepare reports.

Requirements

• BS or master’s degree with over 4 years of experience in a discovery setting using LC-MS/MS within a pharmaceutical or biotechnology company.
• Broad experience in small molecule drug candidate bioanalytical assay development and sample analysis in various biological matrices using LC-MS/MS.
• Experience with AB SCIEX mass spectrometry software.
• Excellent written, verbal communication, and interpersonal skills for collaboration with internal and external partners.

Preferred Qualifications

• Experience with H/UPLC and mass spectrometry.
• Good working knowledge of SCIEX LC-MS/MS systems for small molecule quantitation.
• PK analysis using Phoenix or other data management software.
• Management experience with CROs for outsourcing bioanalytical activities.

Skills

• Strong team orientation; highly collaborative.
• Solutions and results-oriented focus.
• Hands-on approach; resourceful and open to diverse points of view.

Pay

• Research Associate II: $92,891 - $106,507
• Research Associate III: $110,101 - $124,079

Location: Brisbane, CA - Onsite