Research Associate II/III– Bioanalytical/In Vitro ADME/DMPK

About the role

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on discovering, developing, and commercializing targeted protein degradation medicines. The company uses a fully AI-integrated discovery engine and ligase expertise to advance its degrader-based treatments. The position involves supporting Nurix's drug discovery programs through bioanalytical and in vitro DMPK efforts.

Responsibilities

• Provide bioanalytical support for in-house PK, non-GLP safety TK
• Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis
• Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples
• Conduct in-vitro stability assays to understand metabolism of drugs
• Perform metabolic identification (MetID) using LC-QTOF MS/MS, including accurate mass analysis, fragment interpretation and biotransformation pathway assignment
• Independently operate, troubleshoot and maintain LC-MS/MS systems
• Participate in multidisciplinary project teams and collaborate with other departments to understand bioanalytical needs for both PK and PD support
• Manage projects conducted at CROs to ensure high quality bioanalytical data is delivered to meet project timelines
• Maintain accurate and detailed scientific electronic laboratory notebooks

Qualifications

• Extensive experience in bioanalytical method development and sample analysis using LC-MS/MS
• Good working knowledge of SCIEX LC-MS/MS systems for small molecule quantitation
• PK analysis using Phoenix or other data management software
• Management experience with CROs for outsourcing BA activities
• Provide sample analysis to support PK, PK/PD, PK/efficacy, distribution, metabolism, and non-GLP toxicology studies
• Identify issues and troubleshoot scientific equipment including LC-MS/MS, select and develop appropriate methods to perform experiments, analyze data and prepare related reports
• Excellent oral and written communication skills

Preferred Qualifications & Experience

• Experience with H/UPLC and mass spectrometry
• Management experience with CROs for outsourcing BA activities
• Provide sample analysis to support PK, PK/PD, PK/efficacy, distribution, metabolism, and non-GLP toxicology studies
• Identify issues and troubleshoot scientific equipment including LC-MS/MS, select and develop appropriate methods to perform experiments, analyze data and prepare related reports
• Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment

Fit with Nurix Culture and Values

• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Location

Brisbane, CA - Onsite

Salary Ranges

• RA II: $92,891 - $106,507
• RA III: $110,101 - $124,079

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US. Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes. Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).