Regional Business Director, TTR - Northern California

About the role

We are looking for an experienced Regional Business Director to support the promotion of AMVUTTRA® (vutrisiran). The U.S. Food and Drug Administration (FDA) recently approved the supplemental New Drug Application (sNDA) for AMVUTTRA®, expanding its indication to become the first and only therapeutic approved for the treatment of ATTR-CM and the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN) in adults.

The Regional Business Director will lead and manage a high-performing team of Business Account Executives, focusing on disease awareness and product education among healthcare professionals managing hATTR amyloidosis patients. This role offers the opportunity to build a team and shape a market in support of patients, caregivers, and the hATTR amyloidosis community.

The RBD will provide coaching to ensure every Business Account Executive meets or exceeds targets, assess and improve field and selling processes, and provide market insights to inform commercial strategy. The role requires embodying Alnylam’s values: commitment to people, sense of purposeful urgency, passion for excellence, innovation & discovery, open culture, and unwavering integrity. The position reports to the Executive Sales Lead.

Responsibilities

• Lead and manage a high-performing team of Business Account Executives, focusing on disease awareness and product education among healthcare professionals managing hATTR amyloidosis patients.
• Utilize strong sales management, strategic planning, financial acumen, and analytical capabilities to align sales execution with overarching product strategies and market needs.
• Analyze the market and proactively develop a forward-thinking action plan, clearly conveying the current market situation and proposed plan to leadership while ensuring team alignment with future objectives.
• Coach and develop team members to exceed performance targets, emphasizing compliance and effective local business management through strategic business planning and cross-functional alignment.
• Leverage market proximity to provide insights that inform commercial strategy.
• Attract, manage, and retain top sales talent with demonstrated experience in diverse specialties.
• Hold the team accountable for sustaining a customer-oriented culture that prioritizes understanding patient needs, delivering seamless execution, and providing value-added services.
• Allocate and manage regional resources effectively to support targeted strategic and operational excellence.
• Align people, processes, structure, information, and communication systems within a complex ecosystem—both within and across functions.
• Inspire and motivate the team by clearly articulating the strategy and vision for the future.

Requirements

• Bachelor’s degree required; science focus strongly preferred; MBA or PhD is a plus.
• 7+ years of experience in sales, marketing, commercial operations, and/or account management within commercial healthcare organizations (e.g., Biotech, Med Device, or Specialty Pharmaceuticals).
• 3+ years of experience leading teams; experience building out field sales teams preferred.
• Rare/orphan disease experience preferred.
• Experience training and managing Business Account Executives to promote multiple specialties.
• U.S. product launch experience is helpful.
• In-depth reimbursement knowledge of Buy/Bill and expertise in Part B & D, working with in-house patient support services teams.
• Hospital/institution knowledge and expertise with the P&T (Pharmacy & Therapeutics) process.
• Deep experience in Neurology and Cardiology is preferred.
• Knowledge and experience with “site-of-care” development.
• Experience working across various departments and managing multiple teams (sales, marketing, market access, patient services).
• Demonstrated leadership in a matrix environment and influencing management decisions.
• Effective planning, prioritization, management, and organizational skills.
• Familiarity with relevant legal and regulatory environments in the biotech/pharmaceutical industry.
• Significant domestic/regional travel required (approximately 60–70%).
• Valid Driver’s license required.
• Demonstrated commitment to ethics and integrity.

Pay

U.S. Pay Range: $204,000.00 - $276,000.00. The pay range reflects the full-time base salary range expected for this role at the time of posting. Base pay will be determined based on relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Benefits

• Comprehensive medical, dental, and vision coverage.
• Life and disability insurance.
• Lifestyle reimbursement program.
• Flexible spending and health savings accounts.
• 401(k) with a generous company match.
• Paid time off, wellness days, holidays, and two company-wide recharge breaks.
• Generous family resources and leave policies.

About Alnylam

We are the leader in RNAi therapeutics—a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered breakthroughs that made RNAi therapeutics possible and continues to pioneer the field. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture, and commitment to people. We are a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.