RA, Quality Control

Addition Therapeutics is advancing transformative therapies using its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform, enabling RNA-only therapeutics to insert genetic elements into specific safe harbor sites within the genome. Based in South San Francisco, our team drives scientific breakthroughs in a dynamic culture focused on impacting patient lives.

About The Role

• Perform routine in vitro QC release and characterization assays — including cell-based potency/functional assays (e.g., reporter-gene / luciferase), ligand-binding ELISAs, and other plate-based biochemical assays — on materials from Process Development and Formulation.
• Prepare reference standards, standard curves, and serial sample dilutions; interpolate concentrations and determine relative potency using appropriate curve-fitting and quantitative data-analysis methods.
• Apply and monitor assay acceptance criteria and system-suitability metrics to ensure data integrity and assay robustness.
• Execute assays under aseptic technique; troubleshoot assay performance and contribute to method optimization and qualification.
• Maintain, passage, and cryopreserve mammalian reporter and production cell lines under aseptic technique; monitor growth, viability, and confluence.
• Perform routine cell-health checks and mycoplasma testing and manage cell banks and assay reagent inventory.
• Maintain accurate and detailed laboratory records.
• Author and review SOPs, analytical methods, and qualification/validation reports to support QC transfer.
• Partner with Process Development and Formulation to support research and development efforts.

Requirements

• BS or MS in Biology, Biochemistry, Molecular or Cell Biology, Bioengineering, or a related life-science discipline:
  • Bachelor’s degree with 4–5 years of relevant laboratory experience, OR
  • Master’s degree with 1–2 years of relevant laboratory experience.
• Hands-on experience with mammalian cell culture and aseptic technique.
• Experience with cell-based potency/functional assays (e.g., reporter-gene / luciferase) and/or plate-based biochemical assays such as ELISA.
• Proficiency analyzing dose-response data and fitting standard and potency curves using common scientific data-analysis software (e.g., GraphPad Prism, SoftMax Pro, or equivalent).
• Working knowledge of QC principles: assay qualification/validation, acceptance criteria, controls, and metrics such as %CV, dilutional linearity, and parallelism.
• Strong analytical thinking and problem-solving skills.
• Excellent communication and technical writing abilities.
• Ability to thrive in a fast-paced, startup environment.
• Self-motivated, adaptable, and eager to learn.

Preferred Skills

• Experience with high-throughput imaging.

Benefits

• Early scientific contributor to programs with novel biology, a differentiated platform, and validating partnerships.
• Small team with high autonomy; your work directly supports program decisions.
• Work at the intersection of cutting-edge gene therapy and translational science.
• Competitive salary, equity, and benefits.
• Collaborative, no-nonsense lab culture in South San Francisco.

Pay

The hourly rate for this position is $40-$50.

Location: South San Francisco, California