Process Development Scientist, Biocatalysis

About the role

This is a foundational role at Cascade Bio. You will be the person who builds our process development function, setting technical direction, establishing SOPs and standards, and owning the path from bench-scale proof of concept to a process that works at commercial scale. You will work directly with the founding team, with ownership over outcomes and the opportunity to shape not just the science but the culture and direction of the company.

Responsibilities

• Own biocatalytic process development end-to-end, from initial hits to optimized ready to scale processes
• Run and optimize enzymatic reactions, driving process intensification by improving space-time yield, reducing enzyme loading, extending catalyst lifetime, and lowering overall process costs
• Collaborate with our enzyme immobilization team to evaluate and implement biocatalyst formats
• Evaluate and implement new equipment and process analytical technology solutions
• Lead and grow a small process development team over time, mentoring junior scientists while maintaining a technical culture and standards
• Build and maintain techno-economic models tracking key process metrics: E-factor, PMI, catalyst cost contribution, and downstream processing implications
• Interface with protein engineering efforts, translating process bottlenecks into enzyme engineering targets and back-integrating improved variants
• Contribute broadly across the organization: at this stage of the company, the most impactful team members bring their expertise to problems beyond their core scope

Requirements

• PhD or MS in biochemistry, chemical engineering, organic chemistry, or a related field with a strong biocatalysis or heterogeneous catalysis focus
• Minimum of 4 years of experience in process development including scale up, continuous improvements and commercial biocatalysis development
• Demonstrated ability to improve process performance against real commercial targets, including yield, cost, throughput, not just feasibility
• Experience with techno-economic modeling and process analytical tools
• Familiarity with DOE-driven development and comfort using data systematically to guide decisions
• Experience working across disciplines, including protein engineering, analytical chemistry, and engineering, and translating between scientific and commercial priorities
• Prior experience at a biocatalysis-focused company, CDMO, or industrial process chemistry group strongly preferred
• Comfort operating in an early-stage environment with limited resources, ambiguity, and ambitious goals

Qualifications

We are an equal opportunity employer. We welcome and encourage diversity in the workplace and strongly encourage candidates from all backgrounds to apply.

Skills

We are commercializing our Body Armor for Enzymes™, a polymer science innovation that makes enzymes rugged and reliable for cost-effective biomanufacturing. Our platform unlocks the power of enzymes to replace traditional, unsustainable chemical processes and supports the buildout of a resilient and clean chemical industry.

Benefits

At Cascade Biocatalysts, we are passionate about bridging biology and chemistry to build the future of manufacturing. If you're excited to bring enzymes out of the lab and into the world — we’d like to meet you.