Process Development Engineer II, Upstream

About The Role

The Process Development Engineer II supports biotherapeutics process development by executing hands-on cell culture and upstream development experiments. This role involves planning and running studies across a range of upstream unit operations, including bench-top bioreactors, Ambr microscale bioreactors, shake flasks, WAVE bioreactors, and high-throughput purification systems. You will collaborate with senior process engineers to execute complex studies while partnering closely with the broader process development team to generate high-quality data, maintain accurate documentation, and contribute to the optimization of upstream processes. This role also supports laboratory operations by ensuring equipment readiness and reliability.

Responsibilities

• Execute and monitor experiments using cell culture and upstream unit operations (bench-top bioreactors, Ambr, shake flasks, WAVE bioreactors, high-throughput purification systems)
• Operate and monitor bioprocess equipment using DeltaV or similar process control systems
• Maintain laboratory equipment and ensure day-to-day operational readiness
• Partner with senior engineers to plan and execute larger studies and experiments
• Document experimental work in electronic laboratory notebooks with clear, accurate, and timely records
• Perform basic data analysis to evaluate trends and support study conclusions
• Prepare technical summaries and study updates to communicate findings
• Adhere to laboratory procedures, quality standards, and safety requirements
• Support continuous improvement efforts related to workflows, data capture, and execution
• Contribute to project tasks and small initiatives under guidance

Requirements

• Associate’s degree with 2+ years of relevant experience, or Bachelor’s degree in chemical engineering, biological engineering, biotechnology, biology, or a related field, with relevant laboratory or process development experience
• Experience in cell culture, upstream process development, or biotherapeutics development
• Hands-on experience with bioreactors, shake flasks, or related upstream platforms
• Familiarity with DeltaV or similar process control systems
• Experience using electronic laboratory notebooks for documentation
• Ability to perform basic data analysis and clearly communicate findings
• Strong technical writing skills for reports and documentation
• Understanding of laboratory practices, development processes, and quality requirements
• Strong attention to detail with the ability to follow procedures and maintain accurate records
• Ability to work effectively under guidance in a collaborative team environment

Qualifications

• Associate’s degree with 2+ years of relevant experience, or Bachelor’s degree in chemical engineering, biological engineering, biotechnology, biology, or a related field, with relevant laboratory or process development experience
• Experience in cell culture, upstream process development, or biotherapeutics development
• Hands-on experience with bioreactors, shake flasks, or related upstream platforms
• Familiarity with DeltaV or similar process control systems
• Experience using electronic laboratory notebooks for documentation
• Ability to perform basic data analysis and clearly communicate findings
• Strong technical writing skills for reports and documentation
• Understanding of laboratory practices, development processes, and quality requirements
• Strong attention to detail with the ability to follow procedures and maintain accurate records
• Ability to work effectively under guidance in a collaborative team environment

Skills

• Basic data analysis
• Technical writing
• Lab equipment operation
• Process control systems
• Documentation and record keeping
• Collaboration and teamwork

Benefits

At Takeda, we offer a comprehensive benefits package that includes:

• U.S. Base Salary Range: $71,800.00 - $112,860.00
• Short-term and long-term incentives
• Medical, dental, and vision insurance
• 401(k) plan and company match
• Short-term and long-term disability coverage
• Basic life insurance
• Tuition reimbursement program
• Paid volunteer time off
• Company holidays
• Well-being benefits

Pay

U.S. based employees may be eligible for a base salary ranging from $71,800.00 to $112,860.00, depending on various factors including qualifications, experience, and location.

Schedule

This role is full-time and located in Lexington, MA.