Downstream Process Development, Engineer II

Join Takeda as an early-career professional handling problems of limited scope and complexity, adhering to established policies and procedures. Your decision-making will be within a defined scope, using standardized methods to analyze situations and data. You are developing knowledge of basic principles, theories, and concepts, and beginning to apply industry practices and standards.

About the role

The Downstream Process Development, Engineer II supports downstream biotherapeutics process development through hands-on purification and recovery development experiments. This individual contributor role supports process development across multiple scales—from micro scale through bench and pilot scale—and contributes to both early-stage and late-stage programs. You will collaborate with senior process engineers to execute larger experiments and work closely with the process development team to generate data, maintain records, and optimize downstream processes.

Responsibilities

• Execute chromatography, harvest operations, ultrafiltration and diafiltration (UF/DF), and viral clearance experiments, with potential support of bioconjugation.
• Support downstream process development across micro scale, bench scale, and pilot scale studies.
• Maintain laboratory equipment and ensure routine readiness of instruments used in process development.
• Collaborate with senior process engineers to plan and execute larger experiments and study activities.
• Document experimental work in electronic laboratory notebooks and maintain clear, complete, and timely records.
• Perform basic data analysis to review trends, compare conditions, and support study conclusions.
• Prepare technical summaries, study updates, and other written materials to share results and findings.
• Follow established laboratory and process development procedures, including quality and safety requirements.
• Contribute to continuous improvement efforts by identifying ways to improve workflows, data capture, and experimental execution.
• Assist with small projects or specific project tasks under close supervision.

Requirements

• Associate degree with 2+ years of relevant experience, or bachelor’s degree with relevant experience, in chemical engineering, chemistry, biochemistry, biotechnology, or a related field.
• Experience with chromatography, harvest, ultrafiltration and diafiltration, and viral clearance steps.
• Comfort with emerging digital tools and openness to AI-enabled processes that support data analysis, documentation, and workflow improvement.
• Experience with basic bioprocess control systems.
• Experience using electronic laboratory notebooks for study documentation and data entry.
• Ability to perform basic data analysis and present results clearly in written form.
• Familiarity with technical writing for laboratory reports or development documents.
• Understanding of laboratory practices, process development methods, and quality requirements.
• Ability to follow detailed procedures, maintain accurate records, and work under close supervision.
• Some relevant experience in process development, protein purification, or a related laboratory setting.

Important Considerations

• Work in a controlled environment requiring special gowning, including protective clothing over the head, face, hands, feet, and body. This may include additional hearing protection for loud areas.
• Remove all make-up, jewelry, contact lenses, nail polish, and/or artificial fingernails while in the manufacturing environment.
• Work in a cold, wet environment.
• Work multiple shifts, including weekends, or be asked to work supplemental hours as necessary.
• Work around chemicals such as alcohol, acids, buffers, and Celite that may require respiratory protection.

Benefits

• Eligibility for short-term and/or long-term incentives.
• Medical, dental, and vision insurance.
• 401(k) plan with company match.
• Short-term and long-term disability coverage.
• Basic life insurance.
• Tuition reimbursement program.
• Paid volunteer time off.
• Company holidays.
• Well-being benefits.
• Up to 80 hours of sick time per calendar year.
• New hires eligible to accrue up to 120 hours of paid vacation per calendar year.

Pay

U.S. Base Salary Range: $71,800.00 - $112,860.00 for the Lexington, MA location. The actual base salary offered may depend on qualifications, experience, skills, education, certifications, and location.

Schedule

Full time, exempt position.