Process Development Associate I, PRISM High Throughput Screening

About the role

The Broad Institute is seeking an outstanding candidate for the position of Process Development Associate I within the PRISM team, a component of the Cancer Program. Dedicated to transforming medicine, the Broad Institute works to significantly accelerate the understanding and treatment of disease. As part of this important mission, the Cancer Program is advancing the understanding of oncology therapeutics through the systematic profiling of oncology therapeutics using the PRISM technology of large-scale screening of more than 900 cell lines. The chosen candidate will be responsible for processing samples throughout the PRISM screening workflow, including assisting with cell plating, running automated and semi-automated liquid handlers, and large-scale gDNA extractions for library construction. Other responsibilities include maintaining compound and chemical inventories, creating compound assay plates and performing quality-control assessments of our workflows and equipment.

Responsibilities

• Generate large-scale cell-based assay data to support high-throughput production screens
• Assist with large-scale cell plating/treatments for production screens
• Perform high-throughput gDNA extractions and library construction for NextGen sequencing
• Maintain comprehensive lab records, experimental write-ups, and processing notes using an electronic lab notebook (eLabNext)
• Prepare and maintain stocks of reagents, solutions, and lab supplies, managing chemical inventory and compound QC
• Perform basic maintenance on automated lab equipment (e.g., plate washers, combi liquid dispensers, Hamilton automated liquid handlers)
• Investigate issues that arise during screens and help create and precisely execute actionable resolution plans
• Maintain and update SOPs to accurately reflect any changes in production protocols
• Collaborate with the automation team to draft and finalize SOPs for new methods prior to production implementation
• Assist in data QC and review, utilizing an internal data visualization tool
• Participate in team meetings to share results, plan projects, and ensure alignment with current team goals

Minimum Qualifications

• BS/BA in Biology, Biomedical Engineering or related fields
• 1+ year experience in a biological research environment; additional experience with mammalian cell culture is preferred
• Knowledge of high-throughput screening and/or experience working in a high throughput production setting is desired, but not required
• Experience with basic molecular biology techniques, including PCR, DNA extractions, etc
• Excellent written and oral communication skills and ability to effectively work as part of a team
• Strong interpersonal, organizational, and analytical skills, including the ability to handle a variety of tasks in a fast-paced environment
• Strong attention to detail, time management skills, and the ability to maintain accurate records and documentation

Pay

The expected base pay range for this position is $50,000.00/yr - $70,000.00/yr based on a 40 hour per week schedule. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.

Benefits

• Medical, dental, vision, life, and disability insurance
• 401(k) retirement plan
• Flexible spending and health savings accounts
• At least 13 paid holidays; winter closure; paid time off
• Parental and family care leave
• Employee assistance program