Process & Automation Equipment Engineer

About Krystal Bio

Krystal Biotech brings together the brightest and most eager minds to develop genetic medicines for diseases with high unmet medical needs. Founded in 2016, Krystal is distinguished by its patented gene therapy platform, innovative manufacturing, and focus on the patient’s end-to-end experience. Krystal received FDA approval for VYJUVEK®, the first and only redosable gene therapy for Dystrophic Epidermolysis Bullosa (DEB), and continues to advance a pipeline in respiratory, oncology, dermatology, and ophthalmology.

Job Description Summary

Krystal Biotech seeks a motivated and data-driven manufacturing engineer to lead troubleshooting and process optimization in GMP manufacturing. The Engineer will integrate process engineering, automation, and data analytics, supporting development of data-driven monitoring and predictive maintenance programs, and intelligent manufacturing capabilities.

Primary Responsibilities

• Act as primary interface between Manufacturing, Automation, and Facilities teams to diagnose and resolve process and equipment issues.
• Support day-to-day upstream manufacturing operations, ensuring equipment and processes are within validated parameters.
• Develop deep familiarity with control systems and partner with Automation and Facilities teams to troubleshoot issues.
• Identify opportunities to optimize automation configurations and data collection tools.
• Collaborate with Process Development and Manufacturing Sciences to ensure process design aligns with automation behavior.
• Contribute to continuous improvement initiatives and foster a proactive problem-solving culture.

Minimum Qualifications & Desired Competencies

• Bachelor's degree in Engineering or a relevant technical field
• Prior experience in regulated manufacturing or process engineering environment (biotech, pharmaceutical, or adjacent industry)
• Exposure to industrial automation systems (PLCs, HMIs, SCADA platforms)
• Familiarity with GMP principles and documentation standards
• Upstream bioprocessing, cell culture, or bioreactor operations experience
• Process engineering background in biologics / CGT GMP manufacturing
• Hands-on experience with process equipment troubleshooting
• Working knowledge of process controls and automation systems
• Basic understanding of facilities/utilities systems (HVAC, cleanrooms)
• Experience with process data and historians, and data analysis tools
• Interest in predictive maintenance and data analytics
• Strong troubleshooting and analytical skills
• Excellent written and oral communication skills