Principal Scientist, Translational Computational Biology

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients.

About the role

RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA, focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors and aims to be the global leader in radiopharmaceuticals.

Responsibilities

• Lead computational biology strategies supporting discovery and translational research from target identification through clinical development.
• Develop and implement bioinformatics pipelines to analyze genomic, transcriptomic, proteomic, and other multi-omics datasets from preclinical and clinical studies.
• Integrate molecular and clinical data to identify biomarkers, characterize mechanisms of action and resistance, and support patient selection strategies.
• Support Translational Medicine leads in the design and analysis of genomics and other molecular profiling studies using clinical biospecimens to inform biomarker strategies, patient selection, and clinical development.
• Serve as the computational biology lead on cross-functional project teams, providing scientific leadership across Discovery Biology, Translational Science, and Translational Medicine.
• Design and execute computational analyses supporting target validation, biomarker development, pharmacodynamic assessments, and analysis of clinical genomics and multi-omics datasets to enable clinical translation and patient selection.
• Apply statistical, machine learning, and AI-based approaches to extract biological insights and develop predictive models.
• Establish best practices for computational biology, reproducible analytics, and data integration across the organization.
• Champion the evaluation and adoption of AI-enabled technologies to enhance biological data analysis, knowledge discovery, and scientific workflows.
• Partner with internal and external collaborators to develop scalable computational solutions and support translational research strategies.
• Present findings to multidisciplinary teams and senior leadership and contribute to publications, regulatory documents, and scientific presentations.
• Mentor junior scientists and provide technical leadership in computational biology and data science.

Requirements

• BS 8+ years in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline.
• MS 6+ years in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline.
• PhD 4+ years in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline.

Physical Demands & Work Environment

• Regularly required to sit, reach with hands and arms, and communicate effectively.
• Must occasionally lift and/or move up to 30–50 pounds.
• Specific vision abilities required: close vision and distance vision.
• Laboratory and vivarium environment with radioactive and biohazard materials; protective clothing, gloves, and safety glasses are mandatory at all times.
• Noise level is typically moderate.

Pay

San Diego - RayzeBio - CA: $147,956 - $179,288 (full-time employee basis). Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life Benefits:
  • Paid Time Off (US Exempt Employees): Flexible time off (unlimited, with manager approval), 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico, or RayzeBio employees).
  • Phoenix, AZ, Puerto Rico, and RayzeBio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays.
  • Based on eligibility, additional time off may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs, and an annual Global Shutdown between Christmas and New Year's Day.

Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine eligibility. Contractors, leased workers, and other service providers are not eligible to participate in the program.