Principal Scientist, Spatial Omics

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

About the role

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

We are searching for the best talent for a Principal Scientist, Spatial Omics located in Cambridge, MA or Spring House, PA.

Responsibilities

• Lead the development, optimization, and validation of spatial genomics and molecular profiling assays to support neuroscience, oncology, and immunology programs.
• Design and execute experimental workflows involving tissue processing, immunohistochemistry, in situ hybridization, microscopy, high-resolution slide imaging, and sequencing. Experience with Bruker CosMx and 10x Genomics Visium is highly preferred and will be required for this role.
• Establish and refine new molecular assays, including troubleshooting, workflow development, and technical feasibility assessments.
• Build and scale laboratory infrastructure, including lab setup, instrumentation planning, and operational readiness.
• Manage CROs and external partners, ensuring high-quality data generation, timeline alignment, and technical deliverables.
• Collaborate closely with therapeutic area teams to translate multiomics and spatial readouts into actionable biological insights.
• Contribute to data workflows by supporting early-stage data mapping, QC frameworks, and analytical handoffs to computational teams.
• Validate observations in relevant in vitro and ex vivo model systems.

Qualifications

Education:

• Minimum of a PhD in Genetics, Genomics, Molecular Biology, Molecular Pathology, Systems Biology, Human Biology, or a related discipline is required.
• Post-doctoral fellowship in a related field is required. Alternatively, industry experience with a proven track record of delivering completed complex projects will be considered.

Required:

• A minimum of 6 years of biotech or pharmaceutical industry experience is required. Academic staff scientist experience in deeply technical, matrixed, project-facing roles will be considered.
• Strong track record of high-impact scientific deliverables as evidenced by publications, presentations, and recognition within the scientific community.
• Deep, technical spatial omics expertise is required, including understanding of end-to-end workflows, methods limitations, and mitigation strategies.
• Excellent written communication, verbal communication, and oral presentation skills.
• Experience with multiomic datasets.
• Demonstrated ability to work across disciplines and functional areas.
• Ability to apply novel approaches to address complex biology questions, as evidenced through strong peer-reviewed publications.

Preferred:

• Proficiency in programming languages such as R or Python.
• In vitro cell culture and genomics library design experience.
• Experience as a problem solver and team collaborator able to facilitate understanding between biologists and data scientists.
• Ability to manage multiple projects and meet deadlines.
• Experience working with and/or guiding external collaborators in industry or academia.

Pay

The expected pay range for this position is $117,000 to $201,250. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. Bonuses are awarded at the Company’s discretion on an individual basis.

Benefits

Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company-sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). This position is also eligible to participate in the Company’s long-term incentive program.

Subject to the terms of their respective policies and date of hire, employees are eligible for the following time-off benefits:

• Vacation: 120 hours per calendar year
• Sick time: 40 hours per calendar year; for employees who reside in the State of Colorado – 48 hours per calendar year; for employees who reside in the State of Washington – 56 hours per calendar year
• Holiday pay, including Floating Holidays: 13 days per calendar year
• Work, Personal and Family Time: up to 40 hours per calendar year
• Parental Leave: 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave: 240 hours for an immediate family member; 40 hours for an extended family member per calendar year
• Caregiver Leave: 80 hours in a 52-week rolling period
• Volunteer Leave: 32 hours per calendar year
• Military Spouse Time-Off: 80 hours per calendar year