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Jobs · Analyst · New York

Principal Scientist - RGM Chemistry

Regeneron · Hawthorne, NY · 2 wk ago
On-siteAnalyst$129k–$210k/yrFull-time

About the role

We are looking for a visionary Principal Scientist – RGM Chemistry to lead the discovery, development, and optimization of antibody-oligonucleotide conjugation technologies that power next-generation targeted therapeutics.

Responsibilities

  • Designing and completing experiments to refine linker chemistry, payload stability, and delivery efficiency for antibody-oligo conjugates

  • Analyzing conjugates with HPLC, LC-MS, and bioassays to ensure purity, identity, and functional potency

  • Leading project stand-ups, mentoring scientists and research associates, and troubleshooting technical challenges in real time

  • Partnering with Process Development and Manufacturing to scale promising conjugation methods for preclinical supply

  • Scouting and evaluating emerging bioconjugation or RNA delivery technologies, then proposing data-driven innovation projects

  • Presenting program updates and strategic recommendations to senior R&D leadership and cross-functional partners

Requirements

  • A Ph. D. in Chemistry, Biochemistry, Molecular Biology, or related field with 5+ years of postdoctoral or industry experience in antibody/oligonucleotide conjugation

  • Validated expertise in bioconjugation, oligonucleotide therapeutics, and advanced analytical techniques (HPLC, LC-MS, bioassays)

  • Proven leadership of multidisciplinary teams and successful track record in advancing therapeutic candidates toward preclinical or clinical development

Qualifications

  • Deep expertise in bioconjugation, oligonucleotide therapeutics, and advanced analytical techniques (HPLC, LC-MS, bioassays)

  • Strong record of innovation, publications, and/or patents in bioconjugation or RNA therapeutics

  • Ability to balance deep scientific rigor with pragmatic process development and scale-up considerations

  • Motivation to collaborate across functions to accelerate breakthrough medicines to the clinic

Skills

  • Excellent communication and presentation skills

  • Strong problem-solving and critical thinking abilities

  • Ability to mentor and develop talent

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

  • annual bonuses or other incentive plans

  • equity awards

  • pension or retirement benefits

  • 401(k) company match

  • health and wellness programs

  • fitness centers

  • insurance benefits (e.g. medical, dental, vision, life and disability)

  • paid time off

  • family support benefits

Pay

$128,600.00 - $210,000.00 annually

Schedule

Full-time, on-site position

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