Principal Scientist - RGM Chemistry

About the role

We are looking for a visionary Principal Scientist RGM Chemistry to lead the discovery, development, and optimization of antibody-oligonucleotide conjugation technologies.

Responsibilities

• Designing and completing experiments to refine linker chemistry, payload stability, and delivery efficiency for antibody-oligo conjugates
• Analyzing conjugates with HPLC, LC-MS, and bioassays to ensure purity, identity, and functional potency
• Leading project stand-ups, mentoring scientists and research associates, and troubleshooting technical challenges in real time
• Partnering with Process Development and Manufacturing to scale promising conjugation methods for preclinical supply
• Scouting and evaluating emerging bioconjugation or RNA delivery technologies, then proposing data-driven innovation projects
• Presenting program updates and strategic recommendations to senior R&D leadership and cross-functional partners

Requirements

• A Ph. D. in Chemistry, Biochemistry, Molecular Biology, or related field with 5+ years of postdoctoral or industry experience in antibody/oligonucleotide conjugation
• Validated expertise in bioconjugation, oligonucleotide therapeutics, and advanced analytical techniques (HPLC, LC-MS, bioassays)
• Proven leadership of multidisciplinary teams and successful track record in advancing therapeutic candidates toward preclinical or clinical development

Qualifications

• Deep expertise in bioconjugation, oligonucleotide therapeutics, and advanced analytical techniques (HPLC, LC-MS, bioassays)
• Strong record of innovation, publications, and/or patents in bioconjugation or RNA therapeutics
• Ability to balance deep scientific rigor with pragmatic process development and scale-up considerations
• Motivated by cross-functional collaboration that accelerates breakthrough medicines to the clinic

Skills

• Excellent communication and presentation skills
• Strong problem-solving and critical thinking abilities
• Ability to manage multiple projects and priorities simultaneously
• Experience with bioconjugation and oligonucleotide therapeutics

Benefits

At Regeneron, we offer a competitive and comprehensive total rewards package which may include, depending on country and role:

• Annual bonuses or other incentive plans
• Equity awards
• Pension or retirement benefits
• 401(k) company match
• Health and wellness programs
• Fitness centers
• Insurance benefits (e.g. medical, dental, vision, life and disability)
• Paid time off
• Family support benefits

Pay

$128,600.00 - $210,000.00 annually

Schedule

Full-time