Principal Scientist, Preclinical Pharmacology

We need to output HTML fragment with sections: h3 for headings like About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We must include only sections that have real specific content. The posting includes: location (Hybrid - 3x/week onsite in Billerica, MA required). That's schedule? It's location and schedule. Could be Schedule section? The instruction: Use h3 for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). So we can have sections: About the role (maybe intro), Responsibilities (the detailed duties), Requirements (minimum qualifications), Qualifications (maybe preferred qualifications), Skills (maybe not explicit), Benefits (they mention health insurance, PTO, retirement contributions, other perquisites), Pay (they gave range), Schedule (location/hybrid). We must not repeat job title as heading. Also must not include Job ID etc. Remove boilerplate. We need to preserve all substantive info. So we need to extract content. Let's parse: Intro paragraph: "Work Your Magic with us! Start your next chapter and join EMD Serono. Ready to explore, break barriers, and discover more? We know you've got big plans - so do we! Our colleagues across the globe love innovating with science and technology to enrich people's lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us. United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe. This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US." That's about the role/company. Could be "About the role" or "About the company". We'll use "About the role". Then "Your Role The Principal Scientist / Lab Head, In Vivo Pharmacology reports to the Head of Preclinical Pharmacology and is accountable for the scientific, strategic, and operational leadership of the in vivo pharmacology function at the Billerica site. This role establishes, validates, and applies disease models - including immunological, neurological and additional therapeutic areas- to enable discovery and translational research across the N&I portfolio. The Lab Head directly manages a team of scientists and serves as the in vivo pharmacology subject-matter expert on cross-functional project teams spanning biology, DMPK, biomarkers, translational medicine, and pathology. Location: Hybrid - 3x/week onsite in Billerica, MA required." That's responsibilities and location. Then sections: "Scientific & Pharmacology Leadership" bullet list (actually sentences). Then "In Vivo Pharmacology Expertise" bullet list. Then "Leadership and Line Management" bullet list. We can combine these under Responsibilities. Then "Who You Are" with Minimum Qualifications and Preferred Qualifications. Then "Pay Range for this position: $126,900 - 215,400 The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses." Then "Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here." Then "What we offer: ..." That's more fluff, maybe not needed. We need to output only HTML fragment, no markdown. We'll create sections:

About the role

...

Responsibilities

• ...
...

We need to break responsibilities into list items. The posting has many sentences; we can split into logical items. Let's extract responsibilities: - Lead the design, execution, interpretation, and communication of in vivo pharmacology studies in immunology, neuroscience and additional disease areas, delivering actionable scientific recommendations that directly inform N&I program progression decisions. - Establish, validate, optimize, and troubleshoot fit-for-purpose in vivo disease models - including acute and chronic disease-relevant models - to defined validation milestones and reproducibility criteria. - Build and apply immunological and/or neurological disease models to evaluate efficacy, target engagement, pharmacodynamic response, and translational relevance of novel therapeutic approaches, delivering study-ready data packages on schedule and in compliance with protocol and quality standards. - Develop translational in vivo study strategies that connect target biology, pharmacology, PK/PD, biomarkers, and disease-relevant outcomes, enabling evidence-based candidate selection. - Serve as the in vivo pharmacology subject-matter expert on cross-functional discovery and translational project teams, ensuring in vivo data are correctly interpreted and integrated into program strategy. - Provide clear scientific recommendations on model selection, study design, endpoints, dosing regimens, and program progression to accelerate candidate advancement. - Contribute to target validation, candidate selection, mechanism-of-action studies, and translational pharmacology packages supporting IND-enabling decisions. - Hands on execution of in vivo pharmacology studies in disease models - including dosing via IV, SC, IP, PO, ICV, and IT routes, blood and CSF sampling, tissue collection, and necropsy - delivering study-ready samples on schedule and in compliance with protocol and quality standards. - Perform and support surgical procedures relevant to broad set of pharmacology assays, including but not limited to surgical models, ICV/IT administration, stereotaxic injections, surgical recovery monitoring, and clinical scoring, to define procedural and welfare standards. - Support in vivo pharmacology studies by conducting broad, standardized assessments of functional, behavioral, and physiological endpoints across preclinical disease models, enabling robust evaluation of treatment-related effects. - Support biomarker strategy execution, including fluid, tissue, molecular, inflammatory, and translatable biomarker readouts. - Manages CRO partnerships and external study execution, extending the laboratory's capacity and geographic reach, ensuring program timelines are maintained without compromising scientific standards. - Champions IACUC, AAALAC, and GLP compliance across the in vivo function. - Directly manages a team of scientists with full accountability for performance management, scientific development, technical, hands-on training and day-to-day operational oversight. - Maintains the scientific and cultural standards for the in vivo pharmacology function, builds team capability through coaching and structured development planning, and represents the in vivo function at the project team level. - Location: Hybrid - 3x/week onsite in Billerica, MA required. We could put location under Schedule section. Now Requirements (Minimum Qualifications) list: - PhD (+6 years) or MSc (8+ years) in Pharmacology, Neuroscience, Immunology, Biology, or a related life science discipline. - Substantial drug discovery experience in a pharmaceutical or biotech industry setting required. - Proven track record as an in vivo pharmacology workstream lead on a cross-functional drug discovery team. - Familiarity with methods and theory of PK/PD, bioanalysis, imaging, pathology, biomarker strategy, and translational science sufficient to integrate these disciplines into coherent study plans. - Experience with more than one therapeutic modality, such as small molecules, antibodies or other biologics, peptides, oligonucleotides, gene-modulating approaches, or cell-based therapies. - Strong understanding of reproducibility, data integrity, experimental design, and responsible animal research practices. - Experience with protein-based and molecular biomarker assays (ELISA, MSD, cytokine/chemokine panels, IHC). - Experience with IND-enabling study design, execution, and regulatory documentation. - Curious across disciplines and comfortable moving between and across disease areas without overclaiming subject-matter ownership. - Strong scientific communication skills: ability to present data, write reports, and contribute to publications and regulatory documents. - Experience managing or mentoring scientists, preferably including technical specialists and matrixed project teams. - Experience managing CRO partnerships and external academic collaborations. Preferred Qualifications list: - PhD (+8 years) or MSc (10+ years) in Pharmacology, Neuroscience, Immunology, Biology, or a related life science discipline. - Substantial drug discovery experience in a pharmaceutical or biotech industry setting required. - Deep hands-on expertise in in vivo pharmacology across multiple disease areas, including model development, validation, and application in immunology, neuroscience, and at least one additional therapeutic area including rare diseases, metabolic disease; fertility; renal disease; or other complex chronic disease area. - Prior project leadership experience and/or experience leading cross-functional scientific teams and influencing decisions beyond a single disease area or platform. - Strong understanding of how model choice affects biological interpretation, translational relevance, exposure-response relationships, target engagement, and program risk. - Familiarity with methods and theory of PK/PD, bioanalysis, imaging, pathology, biomarker strategy, and translational science sufficient to integrate these disciplines into coherent study plans. - Experience establishing external collaborations, overseeing CRO work, and evaluating partner-generated data. - Significant experience managing or mentoring scientists, specifically including training on highly specialized techniques, training next generation technical specialists and operating within matrixed project teams. We could combine Minimum and Preferred under Requirements and Qualifications sections. The instruction: Use headings like Requirements, Qualifications, Skills. We could put Minimum Qualifications under Requirements, Preferred under Qualifications. Or we could have Requirements (minimum) and Qualifications (preferred). We'll do that. Skills: Not explicitly listed; maybe we can omit Skills section if no specific skills beyond those covered. Better to omit if no real content. Benefits: health insurance, paid time off (PTO), retirement contributions, and other perquisites. Pay: $126,900 - 215,400 plus note about eligibility for bonuses. Schedule: Hybrid - 3x/week onsite in Billerica, MA required. Now we need to output HTML fragment only. We'll wrap each section in

and then

or

• . Make sure not to include empty sections. Let's craft. About the role paragraph: combine the intro paragraphs up to "External applicants must be eligible to work in the US." We'll produce a single

  with that text. Now Responsibilities

  with each responsibility as
  • . We need to ensure we preserve all substantive info; we must not lose any. Let's list responsibilities items as we extracted. We'll need to be careful not to duplicate. Let's write them: 1. Lead the design, execution, interpretation, and communication of in vivo pharmacology studies in immunology, neuroscience and additional disease areas, delivering actionable scientific recommendations that directly inform N&I program progression decisions. 2. Establish, validate, optimize, and troubleshoot fit-for-purpose in vivo disease models - including acute and chronic disease-relevant models - to defined validation milestones and reproducibility criteria. 3. Build and apply immunological and/or neurological disease models to evaluate efficacy, target engagement, pharmacodynamic response, and translational relevance of novel therapeutic approaches, delivering study-ready data packages on schedule and in compliance with protocol and quality standards. 4. Develop translational in vivo study strategies that connect target biology, pharmacology, PK/PD, biomarkers, and disease-relevant outcomes, enabling evidence-based candidate selection. 5. Serve as the in vivo pharmacology subject-matter expert on cross-functional discovery and translational project teams, ensuring in vivo data are correctly interpreted and integrated into program strategy. 6. Provide clear scientific recommendations on model selection, study design, endpoints, dosing regimens, and program progression to accelerate candidate advancement. 7. Contribute to target validation, candidate selection, mechanism-of-action studies, and translational pharmacology packages supporting IND-enabling decisions. 8. Hands on execution of in vivo pharmacology studies in disease models - including dosing via IV, SC, IP, PO, ICV, and IT routes, blood and CSF sampling, tissue collection, and necropsy - delivering study