Principal Scientist, Pharmacology

About Nosis Bio Nosis Bio is a well-funded biotech startup focused on cell-specific delivery of RNA therapeutics. We are an all-scientist team of biologists, chemists, and machine learning experts who believe targeted extrahepatic delivery is the key to making RNA therapies the standard of care for a wide range of chronic diseases. We combine deep expertise in receptor biology, generative AI, and high-throughput in vivo data generation to accelerate the development of RNA therapeutics for new tissues. We are addressing a major unmet need across the industry and actively partner with pharmaceutical companies, research institutions, and biotech companies. About The Role We are seeking a Principal Scientist in Pharmacology to lead molecular biology strategy and execution for studies that characterize the pharmacokinetics, pharmacodynamics, biodistribution, target engagement, and activity of RNA therapeutic candidates. This hands-on scientific leadership role will own studies from experimental design through data interpretation and integrate molecular readouts with in vivo and program data to guide development decisions. The ideal candidate will bring deep expertise in quantitative molecular biology, assay development, and analysis of complex biological samples, with a record of setting technical direction, solving ambiguous scientific problems, and working effectively across pharmacology, discovery biology, chemistry, and data science. Title will be commensurate with experience. Scientific Responsibilities Design and lead quantitative molecular biology studies supporting pharmacokinetic, pharmacodynamic, biodistribution, target engagement, and gene expression assessmentsDevelop, optimize, qualify, and oversee workflows for RNA and DNA extraction, cDNA synthesis, RT-qPCR, qPCR, ddPCR, and related molecular assays across programsEstablish robust sample-processing workflows across cells, tissues, and biofluids, including homogenization, lysis, cleanup, quantification, normalization, and RNase-free handlingTranslate program questions into study strategies with appropriate controls, acceptance criteria, replication, timelines, and sample requirementsAnalyze and integrate complex datasets, including relative and absolute quantification, assay performance metrics, and relationships among molecular, exposure, efficacy, and other pharmacology readoutsLead troubleshooting and root-cause investigations for assay and instrument performance, and implement durable improvements to experimental workflowsEstablish and maintain SOPs, assay qualification summaries, data analysis templates, and training materials that support reproducible execution across the teamEnsure accurate, real-time documentation in the electronic lab notebook, including protocols, raw data, deviations, quality-control decisions, and scientific interpretationCoordinate cross-functionally so sample generation, handling, analysis, and reporting remain aligned with study objectives and program timelinesPresent data with clear context, controls, conclusions, and recommendations, and use the results to guide experimental plans and program decisions Leadership Responsibilities Lead quantitative molecular biology strategy across one or more pharmacology programs, aligning assay plans with biological questions, technical feasibility, and program prioritiesOwn molecular assay platforms end to end, including capability building, performance tracking, risk identification, resource planning, and continuous improvementIdentify and implement new technologies, analytical approaches, and external capabilities that expand the pharmacology toolkitMentor scientists and research associates, providing technical guidance and maintaining a high bar for rigor, reproducibility, documentation, and scientific interpretationServe as a scientific leader across functions and external collaborations, integrating molecular and in vivo evidence into program strategy and scientific communications What we are looking for PhD in Molecular Biology, Biochemistry, Genetics, Pharmacology, Bioengineering, or a related field, or an equivalent combination of advanced training and relevant industry experienceDeep hands-on experience with quantitative PCR methods and molecular assay development, including work with complex tissue or biofluid samplesDemonstrated ability to design pharmacology studies, interpret pharmacokinetic and pharmacodynamic readouts, and integrate molecular results with cross-functional datasetsExperience with RNA therapeutic development including preclinical pharmacology data preparation and presentation for scientific and regulatory interactions. Ability to work on site in our laboratory at Research Park at Marina Village in Alameda, California