Principal Scientist, Platform Architecture & Molecular Selectivity

We need to output only HTML fragment with sections: About the role? Actually "About The Job" is a section heading. Use

for each section heading. We need to include sections only when there is real specific content. We need to parse the posting and extract content. Sections: About the role (or About The Job) -> we can use heading "About the role". Provide prose. Key Responsibilities: list items. Platform Architecture & Selectivity Science: list items. Molecular Readout & Amplification Architecture: list items. Modeling, Data & Validation: list items. Cross-Workstream Technical Leadership: list items. Grants, Intellectual Property & External Engagement: list items. Qualifications: maybe split into Experience and Education? The posting has "Qualifications Experience" and "Education". Could combine as Qualifications section with subpoints? But we need to follow rule: use

for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). So we can have sections: About the role, Responsibilities, Qualifications, Benefits, Pay. Possibly also Skills? But we can incorporate skills within Qualifications. We must not repeat job title as heading. No Job ID. We must include Pay section only if posting states salary. It does: "$180,000 - $190,000 a year" and also California Pay Transparency Statement. So we include Pay section. Benefits section: there is "Benefits & Perks". So include Benefits. Schedule: not mentioned, so omit. We need to preserve all substantive information; do not invent or summarize away detail. So we need to include all details from the posting within sections. We must remove boilerplate: cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, and application instructions. So we need to strip out EEO Statement, Reasonable Accommodation Statement, Why Join Sarmal, Closing Statement, etc. Also remove "Company Overview" maybe? That's part of overview but could be considered part of About the role? The instruction: "Prefer a few substantive sections over many thin ones." We could include Company Overview as part of About the role? But we have "About The Job" heading. The company overview could be placed in About the role section as prose. We'll include it. We need to ensure we don't include duplicated lines. Let's extract content: Company Overview paragraph: "Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights. We are a highly collaborative, R&D-driven team operating in a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications. At Sarmal, we value scientific rigor, curiosity, and a builder mindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality." About The Job paragraph: "We are seeking a Principal Scientist to serve as the principal technical architect of our platform. This role owns the core scientific thesis that sets our technology apart from passive immunoassays: active, multi-layered selectivity applied during the assay itself — built from engineered capture chemistry, directional surface functionalization, molecular (amplification-based) discrimination, and tunable electromodulation of the local interfacial environment. You will define how capture agents are designed and immobilized, how targets are selectively captured and read out, and how protein-capture and nucleic-acid readouts integrate from a single sample input, and you will set the cross-workstream technical roadmap spanning cardiac, sepsis, and epigenomics applications. Your primary objective is to design and execute the proof-of-concept experiments that validate and de-risk each application, then transfer them cleanly to our product development teams for productization. Working at the center of the team, you will define the platform-level architecture that our surface chemistry, biochemistry, molecular biology, and clinical translation scientists build against. This is our most senior individual-contributor scientific role and carries principal technical authority." Key Responsibilities: bullet list under headings: Proof-of-Concept Execution & Technology Transfer - Own the platform's primary objective: design, execute, and interpret proof-of-concept (POC) experiments that establish feasibility and de-risk each application (cardiac, sepsis, epigenomics) - Set clear success criteria, feasibility gates, and readiness milestones that move an assay from concept to demonstrated proof of concept - Package validated POC assays — protocols, characterization data, and design rationale — for clean transfer to the product development teams, and support them through productization and scale-up Platform Architecture & Selectivity Science - Own the multi-layer selectivity model that combines affinity capture, directional surface functionalization, molecular discrimination, and electromodulated tuning to achieve specific capture and release at functionalized electrodes - Direct the design and directional immobilization of capture agents (antibodies, aptamers, engineered binders) on functionalized surfaces (ITO, gold), including bioconjugation, site-specific attachment, and glycan-oxidation / Protein A/G pathways - Define platform performance envelopes — selectivity, capture efficiency, dwell time, and background — and translate them into design requirements for the chemistry, molecular biology, and assay teams - Convert the platform's active, in-assay selectivity into quantitative, defensible advantages over standard immunoassays Molecular Readout & Amplification Architecture - Own the nucleic-acid readout architecture, including immunoRCA / rolling-circle and on-surface primer-extension schemes, ddPCR eluate readout, and barcoding / decoding informatics - Direct primer, probe, and amplification design, and characterize polymerase and enzyme performance (e.g., modified-nucleotide acceptance) for on-surface and solution readouts - Define the integrated protein-capture and nucleic-acid co-read architecture from a single sample input, and the logic for readout-mode selection by application Modeling, Data & Validation - Build data-driven and statistical models of capture / release behavior and selectivity across target classes and sample matrices; lead design of experiments (DOE) and root-cause analysis for platform-level deviations - Establish assay-data infrastructure — schema, pipelines, and visualization — to drive characterization and decision-making across workstreams - Apply statistical inference, machine learning, and quantitative analysis to relate assay conditions to performance (LoD / LoQ, precision, dynamic range, reproducibility) Cross-Workstream Technical Leadership - Serve as principal technical authority across the EPCC, cardiac, sepsis, and epigenomics workstreams - Set experimental standards, review designs, and align cross-functional teams on a shared architecture - Mentor staff and senior scientists and build technical depth across the team Grants, Intellectual Property & External Engagement - Lead SBIR / STTR grant efforts — author proposals and specific aims, and serve as technical lead / principal investigator on awarded programs, managing milestones, budgets, and reporting - Drive invention disclosures and patent strategy around the platform's selectivity and readout approach; partner with patent counsel on filings, claim development, and prior-art / freedom-to-operate review - Represent the platform to partners, collaborators, and investors, and contribute to publications and grant narratives Qualifications Experience: paragraphs: "Experience Demonstrated record translating molecular concepts from bench to validated assay or diagnostic platforms, across graduate and industry research Cross-functional technical leadership across multidisciplinary R&D teams Deep experience in bioconjugation and surface functionalization — directional biomolecule immobilization on solid supports (glass, ITO, gold, or comparable) Strong molecular biology toolkit: PCR / qPCR, primer and probe design, amplification chemistries (RCA / RPA / ddPCR), next-generation sequencing (NGS), and barcoding / decoding schemes Protein engineering, preparation, and characterization (e.g., directed evolution, bioconjugation, analytical and spectroscopic characterization) Quantitative selectivity, sensitivity, dynamic-range, and reproducibility assessment for assays or biosensors Data-science and computational proficiency: Python and/or R, statistical modeling, design of experiments, and assay-data infrastructure; familiarity with machine learning and/or computer vision a strong plus Preferred Microfluidic and/or point-of-care diagnostic development Familiarity with diagnostic performance requirements (LoD / LoQ, precision, interference) and FDA Design Controls / ISO 13485 Exposure to electromodulated or field-tunable capture / release chemistries and to electrochemical characterization (EIS, CV, DPV); deep electrochemistry specialization is not required, as a dedicated electrochemistry sub-team supports the platform Background bridging immunoassay and nucleic-acid (ddPCR / NGS) readout architectures Strong publication and/or patent record" Education: "Education: Ph.D. in Chemistry, Biochemistry, Chemical Biology, Bioengineering, Analytical Chemistry, or a related field Industry Experience: 8 years combined post-doctoral and industry experience developing electrochemical sensing or biosensing platforms" We could combine Experience and Education under Qualifications section. Benefits & Perks: list: - Medical, dental, and vision coverage - Company-paid life insurance - 401(k) retirement plan - Generous paid time off - Access to additional voluntary benefits, employee perks, and discount programs - We are committed to supporting the well-being of our employees and providing a strong foundation for both professional and personal success. Pay: "$180,000 - $190,000 a year California Pay Transparency Statement. The anticipated salary range for this position is $180,000 – $190,000, depending on experience and qualifications. Final compensation will be determined based on a variety of factors including, but not limited to, location, relevant experience, skill set, and internal equity considerations." We need to avoid repeating "California Pay Transparency Statement" maybe but it's part of the content. We'll include it. We must not include EEO Statement, Reasonable Accommodation Statement, Why Join Sarmal, Closing Statement, etc. Now produce HTML fragment with sections:

About the role

Company overview paragraph + About The Job paragraph combined? Could be two paragraphs.

Responsibilities

with subheadings? The rule says use
• for any list of duties/requirements/benefits. It didn't forbid headings inside list? Probably better to keep each responsibility grouping as separate

  ? But we only allowed

  for section headings. Could we embed headings inside

  ? Might be okay but better to keep each responsibility as separate

  with the description. However the responsibilities have subheadings; we could keep them as part of the

  text. Eg:

  Proof-of-Concept Execution & Technology Transfer: ...

  . That preserves content. Similarly for Requirements? Not needed. Qualifications: we can have

  Qualifications

  then
  • each bullet. Benefits:

    Benefits

    . Pay:

    Pay

    . We must not include empty sections. Let's craft. Need to preserve all substantive information: ensure we don't lose any details. Let's write the About the role paragraph: combine company overview and About The Job. Company overview: "Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights. We are a highly collaborative, R&D-driven team operating in a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications. At Sarmal, we value scientific rigor, curiosity, and a builder mindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality." About The Job: "We are seeking a Principal Scientist to serve as