Principal Scientist - Molecular Informatics & Computational Platforms
Johnson & Johnson Innovative Medicine · San Diego, CA · 1 mo ago
HybridAnalyst$117k–$201k/yrFull-time
About the role
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Responsibilities
- Serve as a key agentic-AI enablement leader for ISD: define best practices and help shape the department's agentic strategy.
- Expose computational science capabilities as agent-callable services and help build specialized domain agents, in partnership with platform engineering and portfolio teams.
- Lead design and development of scientific platforms and workflows—including virtual screening, active-learning triage, and ADMET-ML scoring—as reusable, agent-ready components for hit identification and compound optimization.
- Advance small molecule informatics across the DMTA cycle, guiding bench scientists in analysis and decision-making.
- Upskill ISD scientists in agentic-AI tools, prompt engineering, and AI-augmented research practices.
Requirements
- PhD in Cheminformatics, Computational Chemistry, Chemical Engineering, or a related field.
- Minimum of 3 years of industry experience with a proven track record of delivering end-to-end solutions from conceptualization to implementation.
- Hands-on experience with LLM-based tools for scientific workflows (e.g., Claude Code), including skill/prompt engineering and MCP or RAG/knowledge-base integration.
- Deep expertise in cheminformatics software (e.g., KNIME, OpenEye, RDKit) and programming languages (e.g., Python, R), including familiarity with scientific computing and ML libraries (e.g., pandas, scikit-learn, PyTorch).
- Experience with SQL/Snowflake and modeling chemistry data (structures, assay and screening data).
- Comfort with cloud-native and containerized deployment environments.
- Experience working in cross-functional teams and translating ideas from bench scientists to informatics solutions, with excellent problem-solving and communication skills.
Qualifications
- Advanced Analytics
- Coaching
- Critical Thinking
- Data Analysis
- Data Privacy Standards
- Data Quality
- Data Reporting
- Data Savvy
- Data Science
- Data Visualization
- Digital Fluency
- Econometric Models
- Organizing
- Process Improvements
- Strategic Thinking
- Technical Credibility
- Workflow Analysis
Skills
- Advanced Analytics
- Coaching
- Critical Thinking
- Data Analysis
- Data Privacy Standards
- Data Quality
- Data Reporting
- Data Savvy
- Data Science
- Data Visualization
- Digital Fluency
- Econometric Models
- Organizing
- Process Improvements
- Strategic Thinking
- Technical Credibility
- Workflow Analysis
Pay
The anticipated base pay range for this position is: $117,000.00 - $201,250.00
Benefits
- Consolidated Retirement Plan (Pension)
- Savings Plan (401(k))
- Long-Term Incentive Program
- Vacation – 120 hours per calendar year
- Sick time – 40 hours per calendar year; for employees who reside in the State of Colorado – 48 hours per calendar year; for employees who reside in the State of Washington – 56 hours per calendar year
- Holiday pay, including Floating Holidays – 13 days per calendar year
- Work, Personal and Family Time – up to 40 hours per calendar year
- Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
- Caregiver Leave – 80 hours in a 52-week rolling period
- Volunteer Leave – 32 hours per calendar year
- Military Spouse Time-Off – 80 hours per calendar year