Principal Scientist - Medicinal Chemistry

About the Role

In this vital role you will be part of an innovative Medicinal Chemistry group, with responsibilities including the design, synthesis, and purification of novel compounds for potential clinical drug development. This will also include the opportunity to work within Amgen's Induced Proximity Platform (IPP), which is focused on novel and innovative approaches to modulate intractable targets in diseases using the emerging PROTAC modality. This is an onsite laboratory position at our South San Francisco site.

Responsibilities

• Devise and implement state of the art scientific research through conducting laboratory experiments, planning detailed procedures for defined projects including timelines, milestones, methodological approaches, expected results and necessary resources
• Review, analyze, and interpret scientific data and results; providing regular updates, documentation, and/or communication on project results; collaborating with other scientists and keeping current with field of expertise, including literature and technology development
• Additional responsibilities may include advising supervisors and colleagues in areas of expertise; participating in national and international meetings, providing scientific results that support the generation of publications or patents, and mentoring research associates and laboratory assistants

Basic Qualifications

• Doctorate degree and 2 years of scientific experience or
• Masters degree and 5 years of scientific experience or
• Bachelors degree and 7 years of scientific experience

Preferred Qualifications

• Doctorate degree in chemistry specializing in organic chemistry and 6+ years of experience in synthetic organic and medicinal chemistry
• Experience leading medicinal chemistry teams and delivering candidates for clinical development
• Extensive track record of consistent and successful drug discovery accomplishments (e.g. patent inventorship, conference presentations, and peer-reviewed publications)
• Deep understanding of drug discovery and relevant drug discovery disciplines (e.g. chemistry, biology, safety, PKDM, etc.)
• Expert in modern medicinal and synthetic chemistry approaches
• Demonstrated experience managing direct reports
• Excellent collaboration and communication skills (both written and oral)

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Pay

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities.