Principal Scientist - Medicinal Chemistry

Join Amgen’s mission of serving patients. At Amgen, our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With a focus on four therapeutic areas—Oncology, Inflammation, General Medicine, and Rare Disease—we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines.

About the Role

In this vital role, you will be part of an innovative Medicinal Chemistry group, with responsibilities including the design, synthesis, and purification of novel compounds for potential clinical drug development. This will also include the opportunity to work within Amgen’s Induced Proximity Platform (IPP), focused on novel and innovative approaches to modulate intractable targets in diseases using the emerging PROTAC modality. This is an onsite laboratory position at our South San Francisco site.

Responsibilities

• Devise and implement state-of-the-art scientific research through conducting laboratory experiments, planning detailed procedures for defined projects including timelines, milestones, methodological approaches, expected results, and necessary resources.
• Review, analyze, and interpret scientific data and results; provide regular updates, documentation, and/or communication on project results; collaborate with other scientists and keep current with your field of expertise, including literature and technology development.
• Additional responsibilities may include advising supervisors and colleagues in areas of expertise; participating in national and international meetings; providing scientific results that support the generation of publications or patents; and mentoring research associates and laboratory assistants.

Requirements

• Doctorate degree and 2 years of scientific experience or Master’s degree and 5 years of scientific experience or Bachelor’s degree and 7 years of scientific experience.

Qualifications

• Preferred: Doctorate degree in chemistry specializing in organic chemistry and 6+ years of experience in synthetic organic and medicinal chemistry.
• Experience leading medicinal chemistry teams and delivering candidates for clinical development.
• Extensive track record of consistent and successful drug discovery accomplishments (e.g., patent inventorship, conference presentations, and peer-reviewed publications).
• Deep understanding of drug discovery and relevant disciplines (e.g., chemistry, biology, safety, PKDM, etc.).
• Expert in modern medicinal and synthetic chemistry approaches.
• Demonstrated experience managing direct reports.
• Excellent collaboration and communication skills (both written and oral).

Benefits

From our competitive benefits to our collaborative culture, we support your professional and personal growth and well-being. Amgen offers a Total Rewards Plan, based on eligibility, comprising:

• Health and welfare plans for staff and eligible dependents, including group medical, dental, and vision coverage, life and disability insurance, and flexible spending accounts.
• Financial plans with opportunities to save towards retirement or other goals, including a Retirement and Savings Plan with generous company contributions.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models, including remote and hybrid work arrangements, where possible.

Pay

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills, experience, and qualifications.