Principal Scientist in Chemical Induced Proximity

About the role

We are seeking a highly motivated and innovative Principal Scientist with specialized expertise in drug discovery to direct our Chemical Induced Proximity Center in the highly collaborative Department of Chemical Biology and Therapeutics.

Responsibilities

• Drive strategic decisions throughout the various stages of the small molecule drug discovery process focusing on chemically induced proximity platforms.
• Experience with use of computational tools including Artificial Intelligence (AI) and Machine Learning (ML) in virtual screening, small molecule design and optimization is preferred.
• Set up the chemistry strategy for projects and advance drug discovery programs by collaboratively interacting cross-functionally within departmental collaborative centers and various departments at the institution.
• Lead and manage a team of scientists and large-scale, multidisciplinary projects through proactive research collaboration, and provide direction in specific area of expertise.
• Contribute to recruiting and growing the team, guiding and mentoring junior staff.
• Evaluate new technologies, chemical tools, and screening platforms that can accelerate the development of proximity-based therapeutics.
• Design and optimize focused chemical libraries to identify hits, leads, and drug candidates that induce selective protein interactions and cellular phenotypic changes.
• Maintain collaborative partnerships while ensuring recognition on collaborating publications and patents.
• Lead and manage a number of contract research organizations (CRO) and external chemistry partners across the globe.
• Oversee structure-activity relationship (SAR) studies to enhance potency, selectivity, and drug-like properties of candidate molecules.
• Lead efforts to improve the pharmacokinetic, pharmacodynamic, and toxicological profiles of compounds in collaboration with ADMET and DMPK teams.
• Serve as functional expert in due diligences for assets in-licensing and discovery partnerships.
• Responsible for leading publication efforts in high-impact scientific journals.

Requirements

• Experience in drug discovery in Pharma/Biotech industry highly preferred.
• Experience with computational design or AI/ML preferred.
• PhD with management experience preferred.

Qualifications

• Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. PhD preferred.
• Minimum Experience: Fifteen (15) years of relevant work experience is required with a Bachelor's degree. Thirteen (13) years of relevant work experience is required with a Master's degree. Ten (10) years or relevant work experience is required with a PhD.