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Jobs · Information Technology · Massachusetts

Principal Scientist I or II, PK Sciences Therapeutic Areas (Multiple Listings)

Novartis Pharma Schweiz · Cambridge, MA · 1 mo ago
Information Technology$109k–$202k/yrFull-time

About the role

The role is located in Cambridge, USA and involves representing the PK Sciences function in project teams, interactions with stakeholders within the organization, and interactions with regulatory agencies. Key responsibilities include contributing to the development of drug candidates across Research Development and Commercial continuum, providing expert pharmacokinetic / drug metabolism and clinical pharmacology input, working with teams to elucidate PK/PD relationships, developing and executing clinical pharmacology strategies, and driving interdisciplinary collaboration among PK Science disciplines, Drug Disposition (ADME, BA), and Modeling & Simulation (M&S).

Responsibilities

  • Represent the PK Sciences function in project teams, interactions with stakeholders within the organization and interactions with regulatory agencies, as appropriate
  • Proactively contributes to developing drug candidates across Research Development and Commercial continuum, providing expert pharmacokinetic / drug metabolism and clinical pharmacology input
  • Work with teams to elucidate the understanding of PK/PD relationships and develop dosing strategies and predictions
  • Develop and execute clinical pharmacology strategies, including input into nonclinical and clinical study design, and analyzing PK and PK/PD data, to support compound development from discovery through late development
  • Provide PK, dosage, and PK/PD components of study protocols, reports, project summaries and development plans, and author pharmacokinetic/clinical pharmacology/biopharmaceutics sections of IND/IMPDs and NDA/BLAs as well as prepare appropriate responses to Health Authority questions
  • Drive close interdisciplinary collaboration among the PK Science disciplines, Drug Disposition (ADME, BA), Modeling & Simulation (M&S), through PK science sub-teams.
  • Works in close collaboration with clinicians and clinical development colleagues to integrate PKS insights into study design, data interpretation, and project decision-making
  • Use of Artificial intelligence (AI) / Machine Learning (ML) approaches to enable model guided molecular design, preclinical and clinical data automation, authoring regulatory documents, and the use of predictive models

Requirements

  • Ph.D. / Pharm.D. with relevant experience in clinical pharmacology, drug metabolism and pharmacokinetics or a related background
  • A minimum of 0-2 years of experience in drug discovery and/or development in a relevant environment (academia, CRO, biotech or Pharma)
  • 2+ years of experience preferably in a lead role overseeing ADME/DMPK project strategy, either in discovery or clinical development to be considered for Principal Scientist II
  • Extensive and in-depth knowledge of pharmacokinetics including, drug metabolism and PK/PD evaluation, experience in working in project teams (preferably global) as well as sound awareness of recent developments in drug development and regulatory sciences
  • Exposure to working in a cross-functional, matrixed, project-team environment
  • Strong oral and written communication skills

Desirable Requirements

  • Hands-on project experience with Artificial intelligence (AI) / Machine Learning (ML) approaches is a plus

Leadership / Novartis Behaviors in Action

  • Delivers results through disciplined execution, continuous improvement, and a strong focus on value and outcomes
  • Demonstrates an enterprise mindset and strong ownership by prioritizing resources and decisions for maximum Novartis and patient impact
  • Role models Novartis leadership behaviors through visible actions, continuous self reflection, and openness to feedback
  • Buils trust through transparent communication, clear accountability, and consistent delivery against commitments

AI Fluency

  • Brings strong AI and digital fluency, using enterprise tools to enhance insight generation, decision making, and team productivity

Pay

The salary for this position is expected to range between:

  • Principal Scientist I: $108,500 and $201,500 per year.
  • Principal Scientist II: $119,700 and $222,300 per year.

Schedule

The schedule for this position is not specified.

Benefits

This is a dual posting. The final level & title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

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