Principal Scientist - Cancer Early Detection

About the role

The Principal Scientist will lead ICR’s Cancer Early Detection Team, focusing on building early warning systems from arrays of blood- and urine-based biomarkers from cancer patients and healthy controls. The role involves using machine learning to predict cancer signatures to enable early intervention when cancer is most treatable.

Responsibilities

• Lead the development of cutting-edge cancer biomarkers group with the goal of detecting cancer at its earliest stages
• Contribute highly practical and readily translatable pan-cancer screening/early detection, diagnostic, prevention and therapeutic ideas
• Quantify and track cancer biomarkers, including CTCs, cfDNA, serum, plasma, and urine proteins, RNA, metabolites, driver-gene mutations, epigenetic modifications, etc
• Collaborate with ICR’s Biomarkers Team to perform molecular and cellular cancer prevention screening assays, under a personalized medicine paradigm

Requirements

• PhD, MD, or both
• At least 10 years of cancer research experience, preferably in early detection and biomarkers
• Current and in-depth knowledge of pan-cancer: screening, early detection, biomarkers, diagnostic prediction, genetics, prevention, and chemical and vaccine-therapeutics (practical and experimental)
• Programming experience in Python
• Solid grasp of biostatistics, especially probability theory
• Experience with prediction modeling and machine learning, including experience using proper scoring rules
• Idealistically, expert knowledge and understanding of worldwide cancer biomarker and detection assay development pipelines
• Experience with cell-based assays, immunofluorescent microscopy, qPCR, flow cytometry, single-cell genomics, RNAseq, cell culture, organoid culture, Illumina NextSeq 550, DNA methylation sequencing, ddPCR, Luminex, clinical chemistry instrumentation, Kryptor, Access 2, robotic liquid handling (e.g. Tecan), Vortex, and DepArray
• Experience with protein, RNA, and small metabolite cancer biomarker analysis

Qualifications

• Easygoing, friendly personality
• The ability to work in the United States without sponsorship

Skills

• Easygoing, friendly personality
• The ability to work in the United States without sponsorship

Benefits

• Starting base pay range: $165,000/yr - $215,000/yr
• Starting additional compensation range: $7,500/yr - $20,000/yr

Pay

• Starting base pay range: $165,000/yr - $215,000/yr

Schedule

• Not specified