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Jobs · Analyst · Connecticut

Principal Scientist, Biotherapeutics Discovery, Antibody Generation

Boehringer Ingelheim · Ridgefield, CT · 4 wk ago
On-siteAnalyst$140k–$222k/yrFull-time

Duties & Responsibilities

  • Leads a scientific team responsible for generating novel antibodies using cutting-edge in vitro discovery platforms, including phage and yeast display, machine-learning-guided library evolution, and in silico antibody discovery and screening tools.
  • Designs and constructs high-diversity antibody display libraries (phage and yeast) for therapeutic lead identification and affinity maturation.
  • Designs and implements innovative in vitro antibody discovery strategies, including panning, high-throughput screening, and NGS-guided hit prioritization, while integrating AI-accelerated hit identification and automated workflows.
  • Keeps the team at the forefront of emerging discovery technologies, including deep-learning-based binder prediction, ML-guided library design, and structure-enabled computational workflows, making recommendations to advance Boehringer Ingelheim’s internal capabilities.
  • Drives a culture of scientific excellence, innovation, curiosity, and external visibility through publications, conference presentations, and collaborative partnerships.
  • Is familiar with advanced theory and current developments in the field of antibody discovery and makes recommendations to management regarding the advancement of capabilities.
  • Demonstrates clear understanding of research team goals and works effectively toward achieving them;
  • Has ability to participate as co-leader or representative on multiple project teams and contribute to defining expertise-related aspects of overall program goals.
  • PARTNERS WITH PROTEIN ENGINEERING, BIOINFORMATICS, TRANSLATIONAL SCIENCES, AND THERAPEUTIC AREA GROUPS TO ENSURE ALIGNMENT OF ANTIBODY DESIGN WITH PROGRAM GOALS, INCLUDING DEVELOPABILITY, FUNCTIONAL ACTIVITY, AND MANUFACTURABILITY.
  • Maintains meticulous experimental records consistent with SOPs and regulatory expectations.
  • Prepares and delivers clear, compelling technical reports, presentations, and scientific communication to internal leadership and external scientific audiences.
  • Contributes to departmental administration; demonstrates fiscal responsibility with respect to cost of experiments, technology, external collaborations, and travel.

Requirements

  • Requires a PhD plus five (5) years’ industry experience in related field or equivalent.
  • Expertise in phage, yeast, or mammalian display technologies; deep experience in molecular biology, NGS analysis, and antibody library construction.
  • Experience with bioinformatics, computational structural biology, or AI/ML-based sequence or structure modeling strongly preferred.
  • Familiarity with software such as Geneious, GeneData Biologics, PipeBio or other similar tools.
  • One (1) to three (3) years’ experience leading employees and projects is preferred.
  • Requires project management ability and excellent written and oral presentation skills.

Desired Experience, Skills and Abilities

  • Needs experience in one or more of the skills listed above, along with knowledge of the skill center process and the ability to apply those skills to the process.
  • Requires international travel and collaboration.

Eligibility Requirements

  • Must be legally authorized to work in the United States without restriction.
  • Must be willing to take a drug test and post-offer physical (if required).
  • Must be 18 years of age or older.

Compensation Data

This position offers a base salary typically between $140,000.00 and $222,000.00 USD. The position may be eligible for a role-specific variable or performance-based bonus and/or other compensation elements. For an overview of our benefits, please click here.

Our Company

Why Boehringer Ingelheim?

With us, you can develop your own path in a company with a culture that knows our differences are our strengths - and break new ground in the drive to make millions of lives better. Here, your development is our priority. Supporting you to build a career as part of a workplace that is independent, authentic and bold, while tackling challenging work in a respectful and friendly environment where everyone is valued and welcomed. Alongside, you have access to programs and groups that ensure your health and wellbeing are looked after - as we make major investments to drive global accessibility to healthcare. By being part of a team that is constantly innovating, you'll be helping to transform lives for generations.

Want to learn more?

Visit here.

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