Principal Scientist

About the role

Accountable for supporting activities involved in the design, development, transfer, and lifecycle management of manufacturing processes for sterile pharmaceutical products. The candidate selected will be a subject matter expert for PC1 Lifecycle & Lyophilization.

Responsibilities

• Support the design, development, evaluation, and implementation of new or revised manufacturing processes in collaboration with Co-Dev teams and manufacturing operations.
• Design and execute experimental protocols, studies, and measurements to evaluate process performance, variability, scalability, and control of critical process variables.
• Conduct laboratory and engineering studies and analyze data to support product understanding, process performance, technical decision-making, and process improvements.
• Lead or support investigations related to deviations, discrepancies, and process performance issues, including root cause analysis and development of effective CAPA.
• Operate as a strong individual contributor, applying comprehensive knowledge of the discipline, working independently on routine activities, and exercising judgment to resolve moderately complex problems while receiving guidance on more complex challenges.

Requirements

• Applicant must have a bachelor's degree with at least 4 years of experience; OR a master's degree with at least 2 years of experience; OR a PhD with 0+ years of experience; OR an associate's degree with 8 years of experience; OR a high school diploma (or equivalent) and 10 years of relevant experience.
• Experience in Technical Services, Manufacturing Science & Technology (MS&T), or pharmaceutical manufacturing.
• Demonstrated experience in: Process development, validation, or technology transfer; Investigations and troubleshooting of manufacturing processes; Working knowledge of cGMP and regulatory requirements; Strong analytical, problem-solving, and communication skills.

Qualifications

• Bachelor's degree with at least 4 years of experience; OR Master's degree with at least 2 years of experience; OR PhD with 0+ years of experience; OR Associate's degree with 8 years of experience; OR High school diploma (or equivalent) and 10 years of relevant experience.
• Experience in Technical Services, Manufacturing Science & Technology (MS&T), or pharmaceutical manufacturing.
• Demonstrated experience in: Process development, validation, or technology transfer; Investigations and troubleshooting of manufacturing processes; Working knowledge of cGMP and regulatory requirements; Strong analytical, problem-solving, and communication skills.

Skills

• Scientific and engineering principles applied to support the transfer of technology from development into manufacturing.
• Supports the evaluation of process variability, scale-up considerations, and operational constraints.
• Develops robust, compliant, and scalable manufacturing processes, including new or revised process designs.
• Author and review technical reports and provide input on product characterization and analytical methodologies.
• Supports process improvement initiatives, including application of process analytical technologies (PAT) and evaluation and implementation of process, equipment, and system changes.
• Collaborates cross-functionally to ensure process robustness, compliance, supply continuity, and continuous improvement.
• Supports investigations related to deviations, discrepancies, and process performance issues, including root cause analysis and development of effective CAPA.
• Provides technical support and troubleshooting for lyophilization operations.

Benefits

• The annual base salary for this position ranges from $99,200.00 to $165,400.00.
• This position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program.
• We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments.
• Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.

Pay

The annual base salary for this position ranges from $99,200.00 to $165,400.00.

Schedule

Work Location Assignment: Hybrid Limited travel required. Some non-standard work hours support of global conference calls, 24/7 manufacturing, etc. required when needed, though not typical of weekly requirements.