Principal Scientist

About the role

Frontage Laboratories Inc. is an award‑winning, publicly listed, full‑service CRO/Contract Research Organization operating over 25 state‑of‑the‑art laboratories across the US, Canada, and China, with significant year‑over‑year growth. Core competencies include pre‑clinical studies, drug metabolism, pharmacokinetics/pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials. The In vitro ADME Senior/Principal Scientist position is based in Exton, PA within the DMPK (Drug Metabolism & Pharmacokinetics) department on a full‑time basis. The role involves developing, executing, interpreting, and reporting a broad range of in vitro ADME studies to support drug discovery and IND‑enabling programs.

Responsibilities

• Design, perform, troubleshoot, and interpret a broad range of in vitro ADME studies including metabolic stability, CYP inhibition, time‑dependent inhibition (TDI), CYP induction, reaction phenotyping, enzyme kinetics, plasma protein binding, blood‑to‑plasma partitioning, tissue binding, using LC‑MS/MS‑based analytical methods.
• Independently conduct routine and complex ADME assays while ensuring high‑quality data generation and timely project completion.
• Perform sample preparation, LC‑MS/MS analysis, data processing, and result interpretation.
• Prepare study protocols, technical reports, and scientific summaries.
• Troubleshoot experimental and analytical challenges and implement appropriate solutions.
• Maintain laboratory instruments and ensure compliance with SOPs, quality standards, and laboratory safety requirements.
• Support client discussions by providing scientific expertise in study design and data interpretation.

Requirements

• Ph.D. or MS degree in Pharmaceutical Sciences, Analytical Chemistry, Biochemistry, Pharmacology, or a related discipline.
• More than 5 years of relevant industry experience.
• Strong hands‑on experience with multiple in vitro ADME assays.
• Extensive experience with LC‑MS/MS‑based quantitative bioanalysis is preferred.
• Strong troubleshooting and laboratory problem‑solving skills.
• Good written and verbal communication skills.
• Ability to manage multiple studies in a fast‑paced CRO environment.

Benefits

• Competitive compensation.
• Generous benefits package including health and dental insurance.
• 401(k) plan.
• Short‑ and long‑term disability insurance.
• Life insurance.