Principal Research Scientist I (Analytical R&D for LNP and Small Molecule)

Responsibilities

• Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical products to advise the selection of molecules with properties suitable for development.
• Generate new scientific proposals and lead those efforts.
• Anticipate and critically evaluate scientific or regulatory advances or competitive threats and respond with appropriate new strategies.
• Demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
• Embrace the ideas of others, nurture innovation and manage innovation to reality.
• Raise the bar and never be satisfied with the status quo.
• Understand and comply with AbbVie safety, quality and regulatory policies and government regulations.

Qualifications

• Bachelor’s, Master’s, or PhD in Analytical Chemistry typically with a minimum of 14 (BS), 12 (MS), or 6 (PhD) years related industry experience.
• Strong technical background in analytical chemistry, excellent analytical problem-solving skills.
• Capable of independently developing and troubleshooting analytical methods.
• Demonstrated leadership with solving technical challenges across therapeutic modalities, specifically the lipid nanoparticle (LNP) and small molecule spaces.
• Demonstrated experience with a variety of mass spectrometry (MS) instrumentation and applications for structure elucidation and trace quantitation is highly desired.
• Fundamental understanding and working knowledge of various analytical techniques including HPLC, UPLC, GC, DSC, TGA, DVS, PXRD, NMR, dissolution.
• Familiarity with the role that physicochemical properties play in drug delivery and formulation design.
• Working knowledge of typical formulation approaches and routes of administration (i.e. IV, SC, IP, PO) across multiple species.
• Knowledge of preclinical and clinical formulation development principles relevant to lipid nanoparticle formulations.
• Demonstrate creative out-of-the-box thinking to solve difficult problems.
• Self-motivated, hard-working, detail-oriented individual able to work in a fast-paced team environment.
• High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.