Principal Research Scientist I (Analytical R&D for LNP and Small Molecule)

About the role

The qualified candidate will be based at the AbbVie Bioresearch Center in Worcester, MA. However, they must be able to provide 50% on-site support at the AbbVie Bioresearch Center in Worcester, MA and 50% on-site support at the AbbVie Cambridge Crossing site in Cambridge, MA according to project needs.

Responsibilities

• Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical products to advise the selection of molecules with properties suitable for development.
• Generate new scientific proposals and lead those efforts. Anticipate and critically evaluate scientific or regulatory advances or competitive threats and respond with appropriate new strategies.
• Demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.
• Raises the bar and is never satisfied with the status quo.
• Understand and comply with AbbVie safety, quality and regulatory policies and government regulations.

Requirements

• Bachelors, Masters, or Ph.D. in Analytical Chemistry typically with a minimum of 14 (BS), 12 (MS), or 6 (Ph.D.) years related industry experience.
• Strong technical background in analytical chemistry, excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.
• Demonstrated leadership with solving technical challenges across therapeutic modalities, specifically the lipid nanoparticle (LNP) and small molecule spaces.
• Demonstrated experience with a variety of mass spectrometry (MS) instrumentation and applications for structure elucidation and trace quantitation is highly desired.
• Fundamental understanding and working knowledge of various analytical techniques including HPLC, UPLC, GC, DSC, TGA, DVS, PXRD, NMR, dissolution.
• Familiarity with the role that physicochemical properties play in drug delivery and formulation design.
• Working knowledge of typical formulation approaches and routes of administration (i.e. IV, SC, IP, PO) across multiple species.
• Knowledge of preclinical and clinical formulation development principles relevant to lipid nanoparticle formulations.
• Demonstrate creative out-of-the-box thinking to solve difficult problems.
• Self-motivated, hard-working, detail-oriented individual able to work in a fast-paced team environment.
• High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.