Principal Mechanical Engineer, Next-Gen Sequencing Systems, Research & Early Development

About the Position

At Roche, we are working to make next-generation sequencing simple and accessible enough for routine use. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing, resulting in a sample in, result out workflow.

This hands-on role focuses on solving mechanical challenges for our next-generation platforms. You will be responsible for conceptualizing, designing, building, and testing electro-mechanical, pneumatic, thermal, fluidic, and consumable solutions that ensure system performance, reliability, and longevity. As a technical authority, you will drive innovation and define solutions for novel DNA sequencing and automation challenges.

Responsibilities

• Drive the research and development of various sub-systems, encompassing electro-mechanical, pneumatic, thermal, fluidic, and consumable technologies
• Collaborate with cross-functional teams to define and manage critical technical interfaces
• Own sub-systems through verification, integration, and troubleshooting, working closely with System Integration engineers
• Lead cross-functional design reviews to drive alignment and resolve technical trade-offs
• Manage design deliverable timelines and contribute to overall project planning
• Create and maintain comprehensive design documentation
• Contribute to technical strategy, providing data-driven recommendations on architecture and technology
• Present progress, data, and design trade-offs to stakeholders, clearly articulating the impact of engineering decisions

Required Qualifications

• Degree in Mechanical Engineering, or a closely related discipline, with relevant industry experience (minimum 7+ years for a Bachelor's, 4+ years for a Master's, or 3+ years for a PhD)
• Demonstrated hands-on experience designing, developing, and testing complex electro-mechanical, pneumatic, thermal, or fluidic assemblies, preferably for life science or diagnostic instrumentation
• Highly proficient in SolidWorks for detailed design and the creation of manufacturing drawings
• Demonstrated experience designing components for a variety of manufacturing processes (e.g., machining, sheet metal, injection molding, 3D printing)
• Demonstrated problem-solving skills; ability to troubleshoot complex hardware, software, and chemistry interfaces
• Proficient with machine shop tools, measurement equipment, and rapid prototyping (e.g., CNC mills/lathes, laser cutters, 3D printers)
• Experience solving unique or unpredictable problems that might have an impact on the goals and objectives as set by the organization

Preferred Qualifications

• Advanced degree in Mechanical Engineering, or a closely related discipline
• High level of proficiency with Python for device control and data acquisition
• Experience with simulation tools (CFD, FEA) to guide design decisions
• Experience developing next-generation sequencing (NGS) or genomics instrumentation
• Strong interpersonal skills; ability to explain technical concepts to non-experts and thrive in ambiguous environments
• Excellent organizational skills with the ability to manage multiple projects efficiently

Pay

The expected salary range for this position based on the primary location Santa Clara, CA is $110,400 - $205,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

This is an onsite position based in Santa Clara, CA. Relocation benefits are not offered for this role.