Principal Clinical Scientist

About the Role

What if your career-long expertise in clinical trial design and regulatory science could directly influence how AI understands and evaluates medical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to the AI systems being built at the frontier of biomedical research. You'll work alongside world-leading AI labs to ensure that clinical data powering next-generation AI models meets the standards expected in real-world regulatory submissions. This is a fully remote, flexible contract role — work on your own schedule, on your own terms.

Organization: Alignerr
Type: Hourly Contract
Location: Remote
Commitment: 10–40 hours/week

Responsibilities

• Design and critically review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation
• Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance
• Evaluate AI-generated clinical analyses for scientific soundness and alignment with FDA, EMA, or equivalent regulatory standards
• Provide expert, structured feedback that directly shapes how AI models reason about clinical data, trial outcomes, and biomedical evidence
• Identify gaps, errors, or misalignments between AI outputs and real-world regulatory expectations

Requirements

• Senior-level clinical scientist with hands-on experience designing clinical trial protocols for regulatory submission
• Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or their international equivalents
• Strong grounding in clinical research methodology, biostatistics, or translational science
• Rigorous, detail-oriented, and comfortable working independently on complex scientific material
• Clear and precise written communicator — you can articulate nuanced scientific judgment in structured formats

Nice to Have

• Prior experience with data annotation, data quality evaluation, or AI model assessment workflows
• Background in pharmacovigilance, medical affairs, or health technology assessment
• Familiarity with AI tools or scientific evaluation platforms as an end user

Benefits

• Work directly on frontier AI systems making a real impact in clinical and biomedical research
• Influence how the next generation of AI understands, evaluates, and reasons about real-world clinical evidence
• Fully remote and flexible — work when and where it suits you, with no fixed schedule
• Freelance autonomy with the substance of high-impact, expert-level scientific work
• Collaborate with leading AI research teams on problems that matter
• Potential for ongoing work and contract extension as new projects launch