Principal Clinical Scientist

About the Role

What if your career‑long expertise in clinical trial design and regulatory science could directly shape how AI understands and evaluates clinical evidence? We're looking for a Principal Clinical Scientist to bring senior‑level rigor to AI‑driven research workflows. You'll work with cutting‑edge AI systems being developed by leading research labs — ensuring the clinical intelligence built into these models meets the standards expected in real‑world regulatory environments. This is a fully remote, flexible contract role. No AI background needed — just deep command of clinical research and regulatory science.

Organization: Alignerr | Type: Hourly Contract | Location: Remote | Commitment: 10–40 hours/week

What You’ll Do

• Design and review clinical trial protocols used to generate high‑quality, regulator‑ready datasets for AI training.
• Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance.
• Evaluate AI‑generated clinical analyses for scientific soundness and alignment with regulatory expectations (FDA, EMA, or equivalent).
• Provide expert, structured feedback that improves how AI models reason about clinical trial data, endpoints, and outcomes.
• Help define quality standards for clinical data used across frontier AI research projects.

Who You Are

• Senior‑level experience designing clinical trial protocols for regulatory submission.
• Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent bodies.
• Strong background in clinical research methodology, biostatistics, translational science, or a closely related field.
• Naturally rigorous and detail‑oriented — you hold data and analysis to a high standard.
• Able to communicate expert clinical judgment clearly in written feedback.
• Comfortable working independently in a self‑directed, asynchronous environment.

Nice to Have

• Prior experience with data annotation, data quality evaluation, or AI model evaluation workflows.
• Background in pharmacology, clinical pharmacokinetics, or outcomes research.
• Experience working across multiple therapeutic areas or regulatory jurisdictions.
• Familiarity with AI tools or structured evaluation platforms.

Why Join Us

• Work directly on frontier AI systems making a real impact on clinical and biomedical research.
• Fully remote and flexible — work when and where it suits you.
• Freelance autonomy with the structure of meaningful, expert‑level work.
• Influence how AI understands and evaluates real‑world clinical evidence at a foundational level.
• Potential for ongoing work and contract extension as new projects launch.
• Global collaboration with world‑class AI researchers and scientists.