Principal Associate Scientist, RNAi Discovery

Key Responsibilities

• Utilize analytical techniques such as hybridization ELISA, MSD, ELISA, HPLC, Gel Electrophoresis, and Western Blot to support pharmacokinetic and stability analysis of siRNA.
• Effectively troubleshoot and optimize assay conditions and sample preparation protocols to improve assay sensitivity, specificity, and reproducibility.
• Analyze and interpret ligand binding assay data to provide PK insights to present to team members.
• Improve upon and/or develop new methods and automation for analysis of siRNA accumulation and stability.
• Collaborate closely with cross-functional teams including PK/PD, bioanalytical, and discovery groups to integrate assay results.

Qualifications

• Bachelor’s or Master’s degree in Chemistry, Biochemistry, or a related field.
• 5-8 years of work experience, preferably in an industrial setting.
• Attention to detail with a commitment to accuracy and quality in experimental execution and design is highly preferred.
• Hands-on experience with ligand binding assays (e.g., hybridization ELISA, MSD, ELISA) is highly preferred.
• Familiarity with bioanalytical techniques and instrumentation for PK analysis is preferred.
• Experience with assay optimization, validation, and troubleshooting is preferred.
• Familiarity with instrumentation such as HPLC, Gel Electrophoresis, etc. is preferred.
• Ability to function within a highly interdisciplinary environment is a must.
• Excellent written and oral communication skills, good organization skills, the ability to multitask, and the ability to work within a team and/or independently are required.
• Strong commitment to high laboratory and scientific standards and the ability to maintain a safe, clean, and orderly laboratory work environment.

Pay

$95,600.00 - $143,400.00

Schedule

Ongoing

Benefits

Comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave.