Preclinical Programme Leader, Cardiovascular & Metabolic Diseases

We need to produce HTML fragment with sections: About the role? The posting includes "Position Overview" and then responsibilities etc. We need to use

for section headings like About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We should only include sections that have real specific content. The posting includes Position Overview (could be About the role). It includes Key Responsibilities (Responsibilities). It includes Qualifications & Experience (Qualifications). It includes maybe Skills? Not separate. Benefits? The posting mentions "highly competitive compensation package aligned with global industry standards, including attractive benefits and long-term career growth opportunities". That's vague but mentions benefits. It's not specific details; but we can include Benefits section if there is real specific content? It says "including attractive benefits". That's vague but still mentions benefits. The instruction: never create Pay/Schedule/Benefits sections unless the posting actually states them. It does state "highly competitive compensation package ... including attractive benefits". That's a statement about benefits, albeit not detailed. I'd include Benefits section with that sentence. Pay? Not specific numbers, just "highly competitive compensation package". That's vague; but it's about compensation. The instruction says never create Pay section unless posting actually states them. It does state compensation package, but not specific pay. Might be considered stating compensation. However they said avoid filler like "commensurate with experience", "not specified", "N/A", "varies", "TBD". "highly competitive compensation package" is vague but not exactly filler? Might be considered vague but still states that there is a compensation package. I'd include Pay section with that sentence. Schedule? Not mentioned. So omit Schedule. We need to preserve all substantive information, not invent or summarize away detail. We must not repeat job title as heading. No Job ID. Remove boilerplate like "Posted on: July 21, 2026 Apply Here: ..." and navigation etc. Also remove "View All Job Postings >>". Also remove "Global Recruitment & Notes" maybe? That contains some content about global search, compensation package etc. That's substantive? It says "NAT i is conducting a global search...". That's somewhat boilerplate but still part of posting. Might keep as part of About the role? Might be considered boilerplate. The instruction: Remove cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, and application instructions. "Global Recruitment & Notes" is not exactly those; it's more about the search. Might keep as part of About the role. We need to output only HTML fragment, no /, no markdown fences. Structure: maybe not required. Just headings and content. We'll have:

About the role

Position Overview ...

Then

Responsibilities

• ... each responsibility

We need to preserve all responsibilities text. The responsibilities are long with many bullet-like sentences but not formatted as list. We need to convert to

• . We'll split by sentences that start with capital letters and end with period? Better to capture each distinct responsibility as separate
• . The responsibilities section includes multiple paragraphs. We'll parse. Responsibilities text: "Own end-to-end scientific and project strategy for one or more siRNA / ASO discovery programnes from target validation to selection of a Preclinical Candidate in MASH, obesity and/or musculoskeletal diseasesEstablish and execute integrated in vitro and in vivo workflows to support pipeline projects and generate robust high-quality data to support decision-making processDrive clear, go / no-go recommendations based on integrated assessment of biology, PK/PD, and disease-relevant efficacy endpointsEnsure scientific rigour, reproducibility, documentation, and transparency across internal and CRO-executed activitiesActively contribute hands-on laboratory operations as needed to establish platforms, assays, and workflowsOligonucleotide Discovery & ScreeningDesign, execute, and optimise in vitro screening cascades for siRNA / ASO programmes across key metabolic tissues (liver, muscle, adipose), incorporating potency, durability, concentration response curve, and delivery-dependent activityDevelop and deploy mechanistic and functional cell-based assays to link target knockdown with metabolic pathway modulation and disease-relevant phenotypesSupport discovery and optimisation of novel siRNA/ASO delivery platforms, with emphasis on enabling effective extrahepatic cellular uptake and functional knockdownLead hit identification, prioritisation, and lead generation by integrating in vitro potency, functional relevance, delivery compatibility, and translational hypothesesEstablish assay transferability and performance standards for internal execution and CRO deploymentTarget Output: Enable rapid identification of lead siRNA/ASO candidates with validated tissue-specific potency, functional relevance, delivery feasibility, and clear translational readiness for in vivo progressionPharmacology & TranslationDesign, oversee, and interpret in vivo PK/PD, biodistribution, and knockdown efficacy studiesEstablish exposure response and knockdown response relationships to guide lead optimisation and selectionSelect, justify, and govern disease-relevant in vivo models for:MASH: histology, non-invasive fibrosis and inflammation biomarkersObesity: metabolic, cardiometabolic, and weight-related outcomesSkeletal muscle: functional, metabolic, and mitochondrial readoutsTarget Output: Deliver robust in vivo PK/PD and efficacy datasets linking exposure, knockdown, and disease-relevant outcomes across MASH, obesity, and skeletal muscle modelsDisease Biology ExpertiseDeep expertise in liver biology, including:MASH pathophysiologyHepatic lipid metabolism, inflammation, and fibrogenesisTranslational biomarkers relevant to clinical developmentStrong understanding of obesity biology, including:Energy balance and metabolic regulationAdipose tissue inflammation, remodelling, and endocrine signallingWorking knowledge of skeletal muscle metabolism, insulin sensitivity, and glucose utilisationSystems-level understanding of liver-adipose-muscle crosstalk driving metabolic diseaseTarget Output: Apply deep, systems-level disease biology expertise to guide target selection, target validation, in vitro and in vivo model selection to drive the pharmacology and biomarker strategy across liver, adipose, and skeletal muscle in metabolic diseaseScientific Governance, Project Leadership & CollaborationEstablish, author, and maintain SOPs for:In vitro screeningIn vivo PK/PD and efficacy modelsTissue distribution and early tolerability workflowsLead or support IACUC / local animal ethics submissions, umbrella protocols, and regulatory complianceBuild, mentor, and manage junior scientists as programmes and internal capabilities scaleAct as primary scientific and operational interface with CROs, ensuring experimental quality, timelines, data integrity, and budget alignmentServe as the biology/pharmacology point-of-contact with chemistry, bioinformatics, pathology, analytical, and external partnersPartner closely with senior management to align programme execution with portfolio strategy, resourcing, and milestone deliveryTarget Output: Standardised, compliant biology-pharmacology execution delivering high-quality, reproducible data on time and within budget. Aligned teams and partners advancing programmes efficiently against portfolio milestones." We need to split into logical items. Could be each sentence before a capital letter that starts a new responsibility. But many sentences are concatenated without spaces. We need to insert spaces where missing? The text appears to have missing spaces after periods. Eg "...diseasesEstablish". We need to add a space before "Establish". Similarly many. We can manually split by looking for capital letters after a period or after a colon? Let's try to reconstruct. I'll rewrite responsibilities as a list of bullet points based on the logical sections: - Own end-to-end scientific and project strategy for one or more siRNA/ASO discovery programmes from target validation to selection of a Preclinical Candidate in MASH, obesity and/or musculoskeletal diseases. - Establish and execute integrated in vitro and in vivo workflows to support pipeline projects and generate robust high-quality data to support decision‑making process. - Drive clear go/no‑go recommendations based on integrated assessment of biology, PK/PD, and disease‑relevant efficacy endpoints. - Ensure scientific rigour, reproducibility, documentation, and transparency across internal and CRO‑executed activities. - Actively contribute hands‑on laboratory operations as needed to establish platforms, assays, and workflows. - Oligonucleotide Discovery & Screening: Design, execute, and optimise in vitro screening cascades for siRNA/ASO programmes across key metabolic tissues (liver, muscle, adipose), incorporating potency, durability, concentration‑response curve, and delivery‑dependent activity. - Develop and deploy mechanistic and functional cell‑based assays to link target knockdown with metabolic pathway modulation and disease‑relevant phenotypes. - Support discovery and optimisation of novel siRNA/ASO delivery platforms, with emphasis on enabling effective extrahepatic cellular uptake and functional knockdown. - Lead hit identification, prioritisation, and lead generation by integrating in vitro potency, functional relevance, delivery compatibility, and translational hypotheses. - Establish assay transferability and performance standards for internal execution and CRO deployment. - Target Output: Enable rapid identification of lead siRNA/ASO candidates with validated tissue‑specific potency, functional relevance, delivery feasibility, and clear translational readiness for in vivo progression. - Pharmacology & Translation: Design, oversee, and interpret in vivo PK/PD, biodistribution, and knockdown efficacy studies. - Establish exposure response and knockdown response relationships to guide lead optimisation and selection. - Select, justify, and govern disease‑relevant in vivo models for: - MASH: histology, non‑invasive fibrosis and inflammation biomarkers - Obesity: metabolic, cardiometabolic, and weight‑related outcomes - Skeletal muscle: functional, metabolic, and mitochondrial readouts - Target Output: Deliver robust in vivo PK/PD and efficacy datasets linking exposure, knockdown, and disease‑relevant outcomes across MASH, obesity, and skeletal muscle models. - Disease Biology Expertise: Deep expertise in liver biology, including: - MASH pathophysiology - Hepatic lipid metabolism, inflammation, and fibrogenesis - Translational biomarkers relevant to clinical development - Strong understanding of obesity biology, including: - Energy balance and metabolic regulation - Adipose tissue inflammation, remodelling, and endocrine signalling - Working knowledge of skeletal muscle metabolism, insulin sensitivity, and glucose utilisation. - Systems‑level understanding of liver‑adipose‑muscle crosstalk driving metabolic disease. - Target Output: Apply deep, systems‑level disease biology expertise to guide target selection, target validation, in vitro and in vivo model selection to drive the pharmacology and biomarker strategy across liver, adipose, and skeletal muscle in metabolic disease. - Scientific Governance, Project Leadership & Collaboration: - Establish, author, and maintain SOPs for: - In vitro screening - In vivo PK/PD and efficacy models - Tissue distribution and early tolerability workflows - Lead or support IACUC / local animal ethics submissions, umbrella protocols, and regulatory compliance. - Build, mentor, and manage junior scientists as programmes and internal capabilities scale. - Act as primary scientific and operational interface with CROs, ensuring experimental quality, timelines, data integrity, and budget alignment. - Serve as the biology/pharmacology point‑of‑contact with chemistry, bioinformatics, pathology, analytical, and external partners. - Partner closely with senior management to align programme execution with portfolio strategy, resourcing, and milestone delivery. - Target Output: Standardised, compliant biology‑pharmacology execution delivering high‑quality, reproducible data on time and within budget. Aligned teams and partners advancing programmes efficiently against portfolio milestones. That's a lot but we need to preserve all substantive information. It's okay. Now Qualifications & Experience section: "Qualifications & Experience PhD in Molecular Biology, Pharmacology, Biochemistry, or related disciplineA minimum of 4+ (Scientist), 8+ (Senior Scientist), 12+ (Principal Scientist) years of industry experience leading siRNA / ASO discovery programmes, ideally in CVMDStrong hands-on expertise in:Cell-based screening and mechanistic assaysIn vivoPK/PD and knockdown biologyObesity and MASH disease modelsDemonstrated success in early drug discovery, from target validation through hit identification and lead generationExperience establishing new capabilities or platforms and scaling programmes through CRO partnershipsStrong programme management skills with the ability to drive decision-grade outcomesScientifically rigorous, data-driven leader with excellent written and verbal communication skillsCollaborative mentor capable of balancing