Postdoctoral Research Fellow (Mikedis Nicholson) Spermatogensis
Primary Location: Location S; Department: DB - Mikedis; Shift: Day (United States of America); Schedule: Full time; Weekly Hours: 40; FTE: 1; Employee Status: Regular
About the role
Dr. Mikedis Nicholson is looking for a motivated candidate to join her laboratory as a postdoctoral research fellow. The laboratory is particularly interested in how the post-transcriptional control of messenger ribonucleic acid (mRNA) facilitates two distinct stages of development: 1. spermatogonial stem cell differentiation into mitotically dividing progenitors, and 2. progenitors' initiation of meiosis. One of Dr. Mikedis Nicholson's major discoveries is that spermatogonial stem cells require DAZL, an RNA-binding protein, to produce a large progenitor pool. DAZL facilitates progenitor expansion by increasing the translation of its mRNA targets.
Responsibilities
- Develop the skills and knowledge (critical thinking and analysis of data, devising specific aims, long-term project planning and experimental design) to become an independent scientist
- Design, execute, and record laboratory experiments, and analyze data, which may affect decisions regarding future patient care
- Research and improve current methods and evaluate innovative techniques
- Ensure protocol and assay accuracy by conducting regular quality and reproducibility checks
- Implement this knowledge in the Division/Department
- Troubleshoot and correct erroneous results or problems with laboratory equipment
- Discuss relevant insights about experimental results with Faculty and provide useful recommendations and analysis
- Present research at laboratory meetings, journal clubs, seminars, and meetings
- Develop skills to critically review and discuss data being presented
- Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants
- Progressively increasing responsibilities with mentorship of research staff and fiscal administration
- Maintain currency in field through continuing education, literature, and seminars
- Be an active participant in the process through intellectual discussions with PI and other faculty, trainees and research staff
- Solicit feedback on career trajectory from PI, mentoring committee and others who can provide coaching and insight
- Attend required Cincinnati Children’s training sessions and ensure regulatory compliance with all institutional (i.e. Infection Control, ORCRA and others as applicable) policies and procedures
- Perform other duties as assigned