Postdoctoral Research Associate - Gottschalk lab
About the role
The Gottschalk Laboratory is seeking a highly motivated and creative candidate for a fully supported postdoctoral fellowship to develop immune-based therapies. The postdoctoral fellow will join a collaborative research group that strives to build and maintain a culture of respect and collaboration, and the laboratory cares deeply about the success and professional growth of its members. The research project is aimed at developing T-cell-based therapies for pediatric solid and brain tumors. Studies focus on using genetic engineering approaches to render immune cells cancer-specific and improve their effector function. Genetically modified immune cells will be studied in preclinical models with special emphasis on how adoptively transferred cells interact with tumor cells, the tumor microenvironment, and resident immune cells. The ultimate goal is to translate these approaches into early-phase clinical testing.
Responsibilities
- Develop T-cell-based therapies for pediatric solid and brain tumors
- Apply genetic engineering approaches to render immune cells cancer-specific and enhance effector function
- Study genetically modified immune cells in preclinical models
- Investigate interactions between adoptively transferred cells, tumor cells, the tumor microenvironment, and resident immune cells
- Work toward translation of approaches into early-phase clinical testing
Requirements
- Ph.D. or equivalent degree in molecular biology, cell biology, genetics, genomics, immunology, or a related area
- Strong publication record
- Excellent communication skills
- Strong immunology and cell biology background with emphasis on cellular immunology
- Experience with genetic manipulation of mammalian cells
Qualifications
- Experience generating and evaluating human or murine immune cells
- Gene editing expertise
- Single-cell transcriptomics experience
- Flow cytometry proficiency
- Experience with murine solid tumor models