Postdoctoral Research Associate - Chemical Biology and Therapeutics - Cupido Lab

About the role

We are seeking motivated, biology-inclined synthetic chemists to advance the frontier of RNA proximity-induced pharmacology. This project focuses on the discovery, design, and development of small-molecule modulators using novel screening and compound optimization platforms, with an emphasis on undrugged pathways and biological mechanisms regulating RNA biology and gene expression in cancer.

Responsibilities

• Design and execute multistep organic synthesis for small-molecule modulator development.
• Utilize and contribute to novel screening and compound optimization platforms.
• Collaborate with experts in cancer biology, structural biology, and drug discovery.
• Publish research findings in peer-reviewed journals and present at scientific conferences.

Requirements

• Ph.D. in chemistry, chemical biology, or a related field.
• Familiarity with multistep organic synthesis.
• At least one first-author peer-reviewed publication (accepted or near acceptance).

Benefits

• Access to state-of-the-art, fully staffed facilities for chemistry, biophysics, biochemistry, structural biology, mass spectrometry, genomics, cell microscopy, and data-driven discoveries.
• A highly collaborative and supportive research environment with premier experts in cancer biology.
• Opportunities to develop expertise across chemical biology, structural, cellular and molecular biology, proteomics, and drug discovery.
• Strong opportunities for scientific growth, publication, grant writing, collaboration, and career development.

Please direct queries and application materials (cover letter, CV) in a single PDF to Dr. Tommaso Cupido (tommaso.cupido@stjude.org). Applicants should be prepared to provide three letters of reference upon request.