Postdoctoral Fellow, Quantitative Systems Pharmacology

About the role

The Pharmacometrics and Systems Pharmacology group at Pfizer is seeking a postdoctoral fellow to develop, advance, and analyze an end-to-end mechanistic QSP model to better understand therapeutic benefits of incretin therapies beyond weight loss and to generate testable hypotheses for novel mechanisms and indications.

Responsibilities

• Identify and integrate relevant data sources for model development, calibration, and validation, including published literature; internal preclinical and clinical study data; clinical biomarker data; and external real-world and multi-omics resources.
• Apply modeling and simulation approaches to predict clinical outcomes, identify novel indications, and provide novel mechanistic insight into incretin therapies.
• Communicate modeling results and strategic insights effectively to scientists from both quantitative and non-quantitative disciplines.
• Serve as primary author on scientific publications and present research findings at internal and external scientific meetings.

Qualifications

• Ph.D. in Applied Mathematics, Mathematical Biology, Chemical Engineering, Biomedical Engineering, Physics, Pharmaceutical Sciences, Pharmacology, or a closely related discipline with strong numerical components focusing on mathematical modeling and simulation.
• No more than 2 years of post-degree experience.
• Training or previous experience in building QSP or differential-equation-based models of biological or physiological pathways/systems.
• Understanding of theory, principles, and statistical aspects of mathematical modeling and simulation, including parameter estimation techniques.
• Knowledge of modeling, simulation software (MATLAB or Julia preferred), and AI agents.
• Willingness to make a minimum 2-year commitment.
• Successful record of scientific accomplishments evidenced by scientific publications and/or presentations, including at least one first-author publication in a peer-reviewed journal.

Benefits

The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.