Postdoctoral Fellow – Next-Gen Sequencing Systems, Research & Early Development

About the role

At Roche, we are developing the next-generation of sequencing systems. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing workflows.

We are seeking a talented and highly motivated Postdoctoral Fellow with a proven track record of excellence in developing novel technology for biological applications. Joining our Systems Technology Group, you will play a major role in the Research and Early Development of new technology, devices, and instruments associated with our next-generation DNA sequencing and molecular diagnostic platforms. At the heart of these instruments are highly integrated microfluidic systems capable of automating intricate workflows and handling complex biochemistry.

This is a hands-on, interdisciplinary role designed to bridge the gap between biochemical applications and cutting-edge instrumentation. Collaborating closely with a small, agile team and the broader organization, you will solve challenging problems, invent new technology, and ultimately advance the state-of-the-art in DNA sequencing systems.

Responsibilities

• Design, fabricate, and assemble custom devices, fixtures, and breadboards using various rapid prototyping tools, including custom equipment.
• Develop and implement microfabrication processes, including photolithography, etching, drilling, bonding, and dicing—and utilize precision metrology instruments to characterize components and evaluate manufacturing methodologies.
• Create and characterize new materials and bonding methodologies.
• Test, characterize, and troubleshoot complex fluidic systems and devices. Develop and optimize workflows on these systems while collecting, analyzing, and interpreting data to drive technical progress.
• Generate comprehensive test plans, protocols, technical reports, and invention disclosures to document findings and methodology.
• Select, procure, install, validate, operate, repair, and maintain lab/fab equipment and custom instrumentation.

Requirements

• Ph.D. in Bioengineering or a closely related discipline with a thesis focused on solving a molecular biology problem with clever engineering.
• Solid understanding of physics, engineering, chemistry, molecular biology, and sequencing fundamentals.
• Demonstrated experience with advanced microfabrication techniques (lithography, thin-film deposition, wet/dry etching, and thermal fusion bonding processes).
• Demonstrated success porting complex biochemical assays or workflows onto novel fluidic systems and optimizing performance using a systematic approach.
• Solid publication record, including at least one first-authored and peer-reviewed publication in a top-tier journal.
• Demonstrated experience with Python scripting for instrument hardware control.
• Demonstrated interest in market trends; foundational knowledge of peers' work.

Preferred Qualifications

• Experience designing and testing microfluidic systems with active components and integrated sensors.
• Experience building, operating, and troubleshooting fixtures or breadboards with fluidic, pneumatic, thermal, and optical subsystems.
• Proficiency in operating and interpreting data from analytical instruments (e.g., qPCR, dPCR, Bioanalyzer/TapeStation, Qubit, NanoDrop).
• High-level perspective with the ability to see the bigger picture and a desire to challenge the status quo.
• Strong problem-solving, judgment, and decision-making skills; known for high level of attention to detail at scale in a fast-paced environment.
• Strong communication skills, including the ability to communicate with all levels within the organization; hands-on, self-directed, organized, conscientious.
• Strong time management and organizational skills in a dynamic, continually changing environment; ability to communicate effectively (both orally and in writing) with management, peers, and individuals.
• Ability to work effectively, exhibit a professional manner, and establish constructive working relationships.

About Roche Diagnostic’s Postdoctoral Program

Elevate your research career to new heights with Roche Diagnostic’s Postdoctoral Program! Join a prestigious community of early career researchers and kickstart your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Roche Diagnostics' strategic ambitions.

Our program is designed to empower recent PhD graduates to conduct world-class research, publish in top-tier journals, and network within our robust scientific community. By joining us, you will receive the mentorship and support necessary to develop into an independent scientific investigator. As an added benefit, our program will be tied into the long-standing Genentech Postdoc Program with access to world-class seminars and networking opportunities with leading scientists.

Pay

The expected salary range for this position based on the primary location of Santa Clara, CA is $100,000 - $106,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.

Schedule

This position is based onsite in Santa Clara, CA. Relocation benefits are not provided for this role.

Benefits

This position qualifies for the benefits detailed at the Roche Benefits page.