Postdoctoral Fellow in Structural Biology and Enzyme Dynamics, College of Arts and Sciences

About the role

The McLeod Lab at the University of Cincinnati in the Department of Chemistry is seeking a highly motivated postdoctoral fellow to investigate enzyme structure, function, and dynamics using advanced structural biology techniques. Our lab focuses on understanding protein conformational landscapes and enzymatic mechanisms through integrative biophysical approaches.

Responsibilities

• Independently conduct research experiments with rigor
• Interpret data from biophysical and structural experiments
• Familiarize yourself with relevant literature to develop novel ideas for new research directions for both the lab and your future independent career
• Lead the production of manuscripts and presentations for which you will be the first author
• Support the production of manuscripts, presentations, and reports for which you will be an author
• Mentor undergraduate and graduate students in scientific methodology, presentations, & writing
• Help maintain lab equipment and safety protocols

Requirements

• In-depth knowledge of specialized field, process or discipline
• May require experience with specialized software programs

Qualifications

• Ph.D. in Structural Biology, Biochemistry, Biophysics, or a related field
• Extensive experience in protein expression and purification (E. coli)
• Extensive experience with at least X-ray crystallography or cryo-electron microscopy including sample preparation, data collection, and processing
• Excellent problem-solving skills and ability to work independently

Skills

• Independent experimental design
• Data collection and analysis
• Collaboration with interdisciplinary teams
• Remote and/or on-site X-ray scattering and diffraction experiments

Benefits

• State-of-the-art research facilities including a dedicated cryo-EM core facility
• Comprehensive Tuition Remission
• Rothrock Retirement Plan
• Flexible Spending Accounts & Wellness Programs
• Professional Development & Mentorship Opportunities

Pay

Salary/Hourly Pay Rate Information: [[custRCM_PostingSalary]]

Schedule

Flexible start date is available, expected September 2026.

Physical Requirements/Work Environment

Office environment/no specific unusual physical or environmental demands.

Contact Information

To apply, interested candidates should submit the following to mcleodmw@ucmail.uc.edu:

• A cover letter detailing research interests and relevant experience
• A curriculum vitae
• Contact information for three references

Application Process

Review of applications will begin immediately and continue until the position is filled. The expected start date is September 2026, but it is flexible.

Important

To apply you must create a profile and submit a complete job application through the UC applicant portal. We are unable to consider “easy apply” applications submitted via other websites.

Equal Opportunity Employer

Building a workplace where all qualified applicants will receive consideration for employment, including Individuals with Disabilities and Protected Veterans.