Postdoctoral Fellow

About the role

In this vital role you will generate mechanistic insights that directly influence analytical control strategy, molecule design, and formulation development across Amgen's pipeline.

• Design and execute MS-based mechanistic studies of protein fragmentation pathways in biologics, including stable-isotope solvent-labeling approaches such as 18O and 2H218O oxygen-incorporation experiments to distinguish hydrolytic, enzymatic, and chemical fragmentation mechanisms.
• Apply advanced analytical characterization techniques, including mass spectrometry, chromatography, and structural analysis, to identify fragmentation products, map fragmentation sites and characterize reaction intermediates.
• Integrate experimental data with mechanistic and statistical modeling to improve prediction of degradation behavior.
• Translate mechanistic findings into testable hypotheses and practical mitigation strategies, including molecule design (sequence selection), formulation considerations, and storage recommendations.
• Publish findings in high-impact peer-reviewed journals and contribute to intellectual property generation.
• Present research internally and externally at scientific conferences.

Requirements

• PhD at time of appointment

Qualifications

• PhD at the time of appointment in Analytical chemistry, physical chemistry, or related life sciences disciplines
• Demonstration of independent design, execution, and interpretation of experiments and results, as exemplified by a solid publication record with first-author publication(s)
• Demonstrated expertise with ChemDraw and mechanistic biomolecular chemistry, including the ability to propose, illustrate, and evaluate reaction mechanisms relevant to protein and peptide degradation pathways
• Strong understanding of protein chemistry, protein degradation pathways, peptide mapping, and biologics analytical characterization
• Experience with LC-MS/MS, high-resolution mass spectrometry and advanced protein characterization
• Excellent critical thinking, organizational, and communication skills
• Passion to learn and work collaboratively within a large team of scientists with diverse technical and cultural backgrounds

Benefits

• A comprehensive employee benefits package, including:
  • A Retirement and Savings Plan with generous company contributions
  • Group medical, dental and vision coverage
  • Life and disability insurance
  • Flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible

Pay

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.