Postdoctoral Associate

About the role

The Fralin Biomedical Research Institute at VTC in Roanoke, VA, is dedicated to the promotion of health and the prevention and treatment of lifestyle-related disease. The Mishra Laboratory at FBRI is seeking a highly motivated Postdoctoral Associate to work on AHA-funded research projects focused on cardiometabolic disease, heart failure with preserved ejection fraction (HFpEF), mitochondrial biology, cardiac remodeling, and cardiovascular physiology.

Responsibilities

• Designing and conducting independent research studies using in vitro and in vivo models
• Analyzing and interpreting experimental data
• Preparing manuscripts and grant applications
• Mentoring trainees within the laboratory
• Participating in mouse cardiovascular physiology and cardiac disease modeling, including small-animal cardiac surgery models such as transverse aortic constriction (TAC), myocardial infarction (MI), and related models of cardiac stress, remodeling, and heart failure
• Performing mouse echocardiography, exercise interventions, tissue collection, molecular biology, biochemical analyses, and animal colony management

Requirements

• PhD in Cardiovascular Physiology, Molecular Biology, Biochemistry, Exercise Physiology, Biology, Veterinary Sciences, or a related field
• PhD must be awarded no more than four years prior to the effective date of appointment, with a minimum of one year eligibility remaining
• Experience with mouse handling, animal experimentation, and in vivo cardiovascular research models
• Hands-on experience or strong working knowledge of small-animal cardiac surgery models, including TAC, MI, or related models of cardiac injury, remodeling, or heart failure
• Experience in molecular biology techniques including RT-PCR, western blotting, cloning, immunostaining, fluorescence microscopy, mammalian cell culture, and biochemical assays
• Strong scientific writing skills with a demonstrated record of publications and presentations
• Ability to work independently and manage multiple projects
• Ability to stand, walk, stoop, bend for long periods of time

Preferred Qualifications

• Demonstrated experience performing mouse cardiac surgeries, especially TAC, MI, ischemia-reperfusion injury, or related cardiovascular disease models
• Experience with mouse echocardiography and in vivo cardiovascular phenotyping
• Experience with cardiovascular physiology, heart failure, cardiac remodeling, or cardiometabolic disease research
• Experience with metabolism, mitochondrial biology, or molecular mechanisms of cardiac dysfunction
• Experience with exercise physiology and/or HFpEF research
• Prior mentoring or teaching experience