Post Doctorate Fellow, Discovering Receptors That Enable Targeted Oligonucleotide Delivery to Immune Cells

Summary

We are seeking a highly motivated and highly productive Post Doctorate Fellow to contribute to advancing targeted RNA-therapeutics delivery to immune cells. This role offers a unique opportunity to gain deep research experience in a fast-paced industry environment while making a meaningful contribution to the development of next-generation RNA medicines.

Responsibilities

• Identify and prioritize cell-surface receptors relevant to immune-cell biology, applying scientific creativity and critical thinking to advance delivery strategies.
• Validate receptor expression and function using advanced analytical approaches, including flow cytometry, single-cell profiling, and RNA-seq.
• Design and execute in vitro and in vivo studies to evaluate target knockdown, delivery efficiency, and cell-type specificity, exercising sound judgment within established procedures.
• Analyze and interpret complex datasets to guide decision-making, review key technical factors, and shape project strategy.
• Document experimental results and communicate clear, concise findings through regular internal presentations, writing manuscripts for scientific publications, and contributions to posters.
• Collaborate effectively with cross-functional teams and external partners, building alignment around technical decisions and contributing to collective problem-solving.
• Contribute to innovation and intellectual property development through rigorous experimentation and documentation.

Requirements

• Ph.D. in Immunology, Molecular Biology, Cell Biology, or related fields with 0-3 years of postgraduate training
• Familiarity with flow cytometry, including panel design and data analysis
• Experience with cell culture techniques, including primary immune cell isolation and maintenance
• In vivo study experience or willingness to learn
• Experience with molecular biology methods (e.g., RNA analysis, qPCR, siRNA/ASO delivery)
• Strong background in immunology and lymphocyte biology is a plus
• Ability to analyze large datasets (e.g., scRNA-seq, transcriptomics) and interpret receptor expression profiles is a plus
• Excellent problem-solving skills and ability to design experiments independently
• Strong written and verbal communication skills for publication and presentation

Qualifications

• Required to be full-time onsite at Carlsbad, CA

Benefits

Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link

Pay

The pay scale for this position is $65,000 to $87,000