Post-Doctoral Scientist- Immunology Discovery

About the role

Eli Lilly and Company's Immunology organization is seeking a highly motivated Postdoctoral Research Fellow to lead a mechanistic research program comparing two clinically important T cell–redirecting immunotherapy platforms: bispecific T cell engagers (TCEs) and chimeric antigen receptor (CAR) T cell therapies, including transient mRNA-encoded CAR approaches. This is a unique opportunity to conduct hypothesis-driven, publication-caliber research at the interface of basic immunology and translational drug discovery, embedded within an active, industry-leading immunology discovery team.

The postdoctoral fellow will design and execute a systematic, multi-aim research program using established internal reagents, cell lines, and assay platforms, with the goal of generating valuable mechanistic insights.

Responsibilities

• Support immunology research project advancing understanding of T Cell biology in the context of T Cell Engagers and CAR T Cell Therapies
• Work in close collaboration with immunology research, in vivo pharmacology, and bioinformatics groups
• Perform phenotypic and functional characterization of T cells using:
  • Primary human T and B cell isolation and co-culture
  • Multiparameter flow cytometry
  • Multiplex cytokine profiling (MSD)
  • Transcriptional profiling (NanoString; potential single-cell RNA sequencing)

Requirements

• Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field (completed or near completion)
• Strong foundational knowledge of T cell biology
• Must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role

Preferred Qualifications

• Direct research experience with T cell engagers (TCEs) and/or CAR T cell platforms, including cytotoxicity assays and mechanistic characterization
• Hands-on experience with primary human immune cell isolation and culture, multiparameter flow cytometry, and standard immunoassay techniques
• Experience with multiplex cytokine profiling (e.g., MSD), transcriptional profiling (e.g., NanoString or scRNA-seq), and/or lipid nanoparticle–mediated mRNA delivery
• Familiarity with regulatory T cell biology and immune subset dissection techniques
• Excellent communication skills (oral and written) with presentation experience, along with a strong publication record
• Proficient in data analysis and reporting
• Experience with multidimensional flow cytometry
• Experience with scRNA-seq data acquisition and analysis

Additional Information

This position is for a fixed duration of two years with potential to extend to 3 years and for a maximum of up to 4 years. You will have opportunities to apply for full-time positions after your duration is complete.

About Eli Lilly’s Postdoctoral Scientist Program

During your experience you will get:

• Top industry research experience
• Mentoring by some of Lilly’s top scientists
• Laboratory and classroom training and education to further your development
• Collaboration and networking across dozens of postdoctoral scientists and other researchers

Benefits

• Eligibility to participate in a company-sponsored 401(k) and pension
• Vacation benefits
• Medical, dental, vision, and prescription drug benefits
• Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• Life insurance and death benefits
• Certain time off and leave of absence benefits
• Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
• Company bonus (depending, in part, on company and individual performance)

Pay

The anticipated wage for this position is $58,000 - $123,200.