Post Doctoral Fellow-MSH-12908-020

About the role

The Postdoctoral Fellow TR05 position is partially funded by ISMMS and is located at 1468 Madison Avenue, Annenberg 23-16, New York, NY 10029. The PI or Supervisor is John Cijiang He, with a web link to the lab at here. The department is Medicine/Nephrology, and the administrative contact is Irene Beaulieu at Irene.Beaulieu@mssm.edu.

Responsibilities

Background and Description of Research Project: Diabetic kidney disease is a major cause of kidney failure worldwide. Our research focuses on identifying new drug targets to treat this disease using systems biology approaches. Recent findings have identified TENM3 as a key molecule involved in kidney podocyte injury.

• Perform in vitro cell cultures of kidney podocytes and assess the effects of overexpression or knockdown of TENM3 on cell function and downstream signaling pathways.
• Utilize transgenic mouse models with overexpression or knockdown of TENM3 in podocytes to investigate their susceptibility to kidney injury.
• Conduct experiments using techniques such as cell culture, western blot, qPCR, genotyping, mouse breeding, kidney histology analysis, immunostaining, and measurement of urinary albumin and renal function.

Qualifications

• Medical training (MD equivalent) or basic science training with expertise in kidney disease pathogenesis (Nephrology).
• Experience in medical research and proficiency in performing benchwork and animal studies.