Post-Doctoral Fellow - Lab of Dr. Tyagi

About the Role

A highly motivated Postdoctoral Fellow is sought to join a laboratory investigating the molecular and cellular mechanisms underlying HIV persistence, neuroinflammation, accelerated aging, and neurodegeneration. The lab utilizes cutting-edge human induced pluripotent stem cell (iPSC)-derived microglia, cerebral organoids, and advanced genomic approaches to identify novel therapeutic targets and develop innovative interventions for HIV-associated and age-related neurological disorders.

The successful candidate will participate in multidisciplinary projects focused on understanding how HIV infection, chronic inflammation, and drugs of abuse alter brain function and contribute to neurocognitive impairment, neurovascular dysfunction, and accelerated aging.

Candidates with experience in human iPSC-derived microglia, brain organoids, neuroinflammation, HIV biology, or single-cell genomics are particularly encouraged to apply.

Research Experience

• Human iPSC-derived microglia and other brain cells
• Generation and characterization of cerebral and brain organoids
• HIV infection and persistence in the central nervous system
• Neuroinflammation and inflammasome signaling
• Aging and age-associated neurodegenerative mechanisms
• HIV infection and latency models
• CRISPR/Cas genome engineering
• Single-cell RNA sequencing (scRNA-seq)
• Other common molecular and cellular biology techniques

Responsibilities

• Design and conduct independent research projects
• Mentor students, junior, and other laboratory personnel
• Analyze and interpret experimental data
• Prepare manuscripts for publication
• Present findings at scientific meetings
• Assist with reagent ordering, storage, and laboratory organization
• Maintain detailed laboratory records
• Provide a brief daily report on lab activity and planning for the next day

Qualifications

• Ph.D. in Neuroscience, Cell Biology, Molecular Biology, Immunology, Virology, Stem Cell Biology, Biomedical Sciences, or a related field
• Strong publication record demonstrating research productivity

Benefits

Jefferson offers a comprehensive package of benefits for full-time and part-time colleagues, including:

• Medical (including prescription), dental, and vision insurance
• Supplemental insurance (life, AD&D, short- and long-term disability)
• Flexible spending accounts
• Retirement plans
• Tuition assistance and discounts at Thomas Jefferson University after one year of full-time service or two years of part-time service
• Voluntary benefits, including group insurance rates and discounts

All colleagues, including those who work less than part-time (per diem, adjunct faculty, and Jeff Temps), have access to medical (including prescription) insurance.

Schedule

Workday, day shift (United States of America).