PhD Opportunity: Gene Therapy & Genome Editing for Hearing Disorders | Institut Pasteur, Paris

About the role

We are looking for an outstanding and highly motivated PhD candidate to join the RESTORE project at the Institut reConnect, Institut Pasteur in Paris. The project will develop next‑generation AAV gene therapy and precision genome editing for Usher syndrome, building on unique humanized mouse models and strong in vivo proof‑of‑concept data. The successful candidate will investigate how therapeutic efficacy, intervention timing and long‑term safety determine functional rescue of the inner ear.

Responsibilities

• Investigate how therapeutic efficacy, intervention timing and long‑term safety determine functional rescue of the inner ear.
• Contribute to the development of next‑generation AAV gene therapy and precision genome editing approaches for Usher syndrome.
• Perform multidisciplinary work spanning gene therapy, CRISPR‑based genome editing, sensory neuroscience, advanced imaging and in vivo functional phenotyping.

Requirements

• Excellent academic record with a background in molecular/cell biology, neuroscience, genetics or biotechnology.
• Strong motivation and scientific curiosity to tackle challenging biomedical questions.

Qualifications

• Prior expertise in gene therapy or genome editing is advantageous but not required.
• Ability to work in an internationally recognized research environment and engage in multidisciplinary training.